(Q40631570)

22 September 2017

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors (English)

1 reference

22 September 2017

Adeela Kamal

1

1 reference

22 September 2017

Lia Thao

2

1 reference

22 September 2017

John Sensintaffar

3

1 reference

22 September 2017

Lin Zhang

4

1 reference

22 September 2017

Marcus F. Boehm

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14508491

14 March 2024

Lawrence C. Fritz

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14508491

14 March 2024

Francis J. Burrows

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14508491

14 March 2024

language of work or name

English

0 references

publication date

1 September 2003

1 reference

22 September 2017

25 September 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14508491

full work available at URL

14 March 2024

http://www.nature.com/articles/nature01913.pdf

file format

Portable Document Format

1 reference

http://www.nature.com/articles/nature01913

14 March 2024

1 reference

14 March 2024

1 reference

22 September 2017

425

1 reference

22 September 2017

407-410

1 reference

22 September 2017

6956

1 reference

https://scigraph.springernature.com/pub.10.1038/nature01913

22 September 2017

0 references

cites work

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Geldanamycin-induced destabilization of Raf-1 involves the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Telomerase as a Target for Cancer Immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Hsp90: chaperoning signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

The assembly of progesterone receptor-hsp90 complexes using purified proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Expression and roles of heat shock proteins in human breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Hsp90 as a capacitor for morphological evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

Hsp90 as a capacitor of phenotypic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE01913

inferred from DOI database lookup

7 January 2021

based on heuristic

9

54

2724

P Miller

1994

1 reference

14 March 2024

27

54

547

TM Gress

1994

1 reference

14 March 2024

Identifiers

DOI

10.1038/NATURE01913

1 reference

Dimensions Publication ID

22 September 2017

0 references

1 reference