(Q40634279)

22 September 2017

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title

Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency (English)

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22 September 2017

J Chehimi

1

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PubMed ID

7929692

22 September 2017

G Trinchieri

series ordinal

2

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22 September 2017

1 May 1994

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Journal of Clinical Immunology

22 September 2017

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22 September 2017

14

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22 September 2017

149-161

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22 September 2017

3

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https://scigraph.springernature.com/pub.10.1007/bf01533364

22 September 2017

0 references

cites work

Cell-mediated immune response to human immunodeficiency virus (HIV) type 1 in seronegative homosexual men with recent sexual exposure to HIV-1.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF01533364

Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells

21 January 2018

1 reference

12 December 2020

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)

1 reference

12 December 2020

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts

1 reference

12 December 2020

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

1 reference

12 December 2020

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients

1 reference

12 December 2020

Induction of interleukin 12 responsiveness is impaired in anergic T lymphocytes

1 reference

12 December 2020

Natural Immunity: A T-Cell-Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1 reference

12 December 2020

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

12 December 2020

Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines

1 reference

12 December 2020

Human TH1 and TH2 subsets: doubt no more

1 reference

12 December 2020

IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts

1 reference

12 December 2020

Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells

1 reference

12 December 2020

Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells

1 reference

12 December 2020

Multifactorial nature of human immunodeficiency virus disease: implications for therapy

1 reference

12 December 2020

Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent

1 reference

12 December 2020

Use of IFN-gamma in patients with AIDS

1 reference

12 December 2020

Differentiation and proliferation of hematopoietic stem cells

1 reference

12 December 2020

Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation

1 reference

12 December 2020

T helper cell immune dysfunction in asymptomatic, HIV-1-seropositive individuals: the role of TH1-TH2 cross-regulation

1 reference

12 December 2020

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

1 reference

12 December 2020

Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF

1 reference

12 December 2020

Reduced production of interleukin 2 and interferon-gamma and enhanced helper activity for IgG synthesis by cloned CD4+ T cells from patients with AIDS

1 reference

12 December 2020

Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro

1 reference

12 December 2020

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype

1 reference

12 December 2020

T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function?

1 reference

12 December 2020

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

1 reference

12 December 2020

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection

1 reference

12 December 2020

Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.

1 reference

12 December 2020

Regulation of human cytolytic lymphocyte responses by interleukin-12

1 reference

12 December 2020

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

1 reference

12 December 2020

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1 reference

12 December 2020

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

1 reference

12 December 2020

A TH1-->TH2 switch is a critical step in the etiology of HIV infection

1 reference

12 December 2020

Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation

1 reference

12 December 2020

Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs

1 reference

12 December 2020

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones

1 reference

12 December 2020

Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not on Th2 cells

1 reference

12 December 2020

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes

1 reference

12 December 2020

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

1 reference

12 December 2020

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

1 reference

12 December 2020

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

1 reference

12 December 2020

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells

1 reference

12 December 2020

Interleukin 12 in host defense against microbial pathogens

1 reference

12 December 2020

Antitumor and antimetastatic activity of interleukin 12 against murine tumors

1 reference

12 December 2020

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

1 reference

12 December 2020

Pathogenesis of human immunodeficiency virus infection

1 reference

12 December 2020

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist

1 reference

12 December 2020

A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells

1 reference

12 December 2020

Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture

1 reference

12 December 2020

Interleukin-12 and its role in the generation of TH1 cells

1 reference

12 December 2020

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

1 reference

12 December 2020

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

1 reference

12 December 2020

The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

1 reference

12 December 2020

Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2.

1 reference

12 December 2020

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

1 reference

12 December 2020

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2

1 reference

12 December 2020

The immunopathogenesis of HIV infection

1 reference

12 December 2020

Cloning and expression of murine IL-12

1 reference

12 December 2020

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.

1 reference

12 December 2020

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes

1 reference

12 December 2020

The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

1 reference

12 December 2020

Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome

1 reference

12 December 2020

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

12 December 2020

1 reference

12 December 2020

Cytokine cross-talk between phagocytic cells and lymphocytes: relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity

1 reference

12 December 2020

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes

1 reference

12 December 2020

Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56+ natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12

1 reference

12 December 2020

IL-12: initiation cytokine for cell-mediated immunity

1 reference

12 December 2020

Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12

1 reference

12 December 2020

Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5

1 reference

12 December 2020

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

1 reference

12 December 2020

Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?

1 reference

12 December 2020

Recombinant interleukin 12 cures mice infected with Leishmania major

1 reference

12 December 2020

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation

1 reference

12 December 2020

Interferon gamma inhibits interleukin 10 production by monocytes

1 reference

12 December 2020

Modulation of perforin and granzyme messenger RNA expression in human natural killer cells.

1 reference

12 December 2020

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection

1 reference

12 December 2020

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells

1 reference

12 December 2020

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

1 reference

12 December 2020

Impaired interleukin 12 production in human immunodeficiency virus-infected patients

1 reference

12 December 2020

Differential effects of tyrosine kinase inhibition in CD69 antigen expression and lytic activity induced by rIL-2, rIL-12, and rIFN-alpha in human NK cells

1 reference

12 December 2020

Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells

1 reference

12 December 2020

IL-12 receptor. II. Distribution and regulation of receptor expression

1 reference

12 December 2020

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

1 reference

12 December 2020

Molecular characterization of interleukin 12

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01533364

1 reference

PubMed ID

7929692

Dimensions Publication ID

22 September 2017

0 references

1 reference

PubMed ID

7929692