(Q40645305)

22 September 2017

1 reference

title

Genetic differences in drug disposition (English)

1 reference

22 September 2017

May DG

1

1 reference

22 September 2017

1 September 1994

1 reference

The Journal of Clinical Pharmacology

22 September 2017

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22 September 2017

34

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22 September 2017

881-897

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22 September 2017

9

1 reference

Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility

22 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Red cell abnormalities associated with sulphasalazine maintenance therapy for ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Multiple N-acetyltransferases and drug metabolism. Tissue distribution, characterization and significance of mammalian N-acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

N-acetylation polymorphism of dapsone in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The influence of enzyme induction on polymorphic sparteine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Metoprolol and debrisoquin metabolism in Nigerians: lack of evidence for polymorphic oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Evidence for the polymorphic oxidation of debrisoquine in the Thai population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Oxidation phenotyping in Chinese and Malay populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Sparteine oxidation polymorphism in Greenlanders living in Denmark

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

A family study of genetic and environmental factors determining polymorphic hydroxylation of debrisoquin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Mephenytoin hydroxylation deficiency: kinetics after repeated doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

S-mephenytoin 4-hydroxylase is inherited as an autosomal-recessive trait in Japanese families

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Mephenytoin hydroxylation in the Cuna Amerindians of Panama

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human genes for glutathione S-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The glutathione S-transferases: polymerase chain reaction studies on the frequency of the GSTM1 0 genotype in patients with pituitary adenomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hbsubunit cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human erythrocyte thiol methyltransferase: radiochemical microassay and biochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Pharmacogenetics of aldehyde dehydrogenase (ALDH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Expression of CYP2D6 in developing human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Human glutathione S-transferases: radioimmunoassay studies on the expression of alpha-, mu- and pi-class isoenzymes in developing lung and kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The development expression of alpha-, mu- and pi-class glutathione S-transferases in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Two distinct forms of glutathione transferase from human foetal liver. Purification and comparison with isoenzymes isolated from adult liver and placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Developmental changes and polymorphism in human alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

A simple test for acetylator phenotype using caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Dextromethorphan and caffeine as probes for simultaneous determination of debrisoquin-oxidation and N-acetylation phenotypes in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Dextromethorphan phenotypes in paediatric patients with autoimmune hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Encainide and its metabolites. Comparative effects in man on ventricular arrhythmia and electrocardiographic intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Oral flecainide pharmacokinetics in patients with impaired renal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Drug interaction between propafenone and metoprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Impact of environmental and genetic factors on codeine analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Substantial rise in sparteine metabolic ratio during haloperidol treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Childhood leukaemia: a relationship between intracellular 6-mercaptopurine metabolites and neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Polymorphic N-acetylation capacity in lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Debrisoquine oxidation phenotype and susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genetically determined debrisoquine oxidation capacity in bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Glutathione S-transferase μ in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Effect of acetylator phenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Oxidative polymorphism of debrisoquine in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Poor hydroxylator phenotypes of debrisoquine and S-mephenytoin are not over-represented in a group of patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genetic predisposition to phenytoin-induced birth defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Stereoselective disposition and pharmacologic activity of propafenone enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJ.1552-4604.1994.TB04001.X

10.1002/J.1552-4604.1994.TB04001.X

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

7983231