(Q40696570)

22 September 2017

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation (English)

1 reference

22 September 2017

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2

Carol Prives

1 reference

22 September 2017

Jinwoo Ahn

1

1 reference

PubMed ID

12386164

22 September 2017

language of work or name

English

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publication date

16 October 2002

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

277

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22 September 2017

48418-48426

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22 September 2017

50

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Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

CHK2 kinase--a busy messenger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Characterization of tumor-associated Chk2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

The FHA domain is a modular phosphopeptide recognition motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Structure and function of a new phosphopeptide-binding domain containing the FHA2 of Rad53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Use of fast protein size-exclusion liquid chromatography to study the unfolding of proteins which denature through the molten globule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Domain structure of the HSC70 cochaperone, HIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Transfection-mediated cell-cycle signaling: considerations for transient transfection-based cell-cycle studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Concomitant inactivation of p53 and Chk2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Characterization of the interactions between human cdc25c, cdks, cyclins and cdk-cyclin complexes 1 1Edited by J. Karn

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

Probing the three-dimensional structure of human calreticulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208321200

21 January 2018

Identifiers

DOI

10.1074/JBC.M208321200

1 reference

22 September 2017

1 reference

PubMed ID

12386164