(Q40701934)

22 September 2017

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays (English)

1 reference

22 September 2017

Falgun Shah

1

1 reference

22 September 2017

Louis Leung

2

1 reference

22 September 2017

Hugh A Barton

3

1 reference

22 September 2017

Yvonne Will

4

1 reference

22 September 2017

A David Rodrigues

5

1 reference

22 September 2017

Nigel Greene

6

1 reference

22 September 2017

Michael D Aleo

7

1 reference

22 September 2017

23 July 2015

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22 September 2017

Toxicological Sciences

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22 September 2017

147

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22 September 2017

500-514

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22 September 2017

2

1 reference

Toward predictive models for drug-induced liver injury in humans: are we there yet?

22 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

FDA-approved drug labeling for the study of drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Predicting in vivo safety characteristics using physiochemical properties and in vitro assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

LiverTox: a website on drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Impact of OATP transporters on pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

A multiple-ascending-dose study to evaluate safety, pharmacokinetics, and pharmacodynamics of a novel GPR40 agonist, TAK-875, in subjects with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Concordance of the toxicity of pharmaceuticals in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Analysis of Pfizer compounds in EPA's ToxCast chemicals-assay space

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Pharmacokinetic evaluation of desogestrel as a female contraceptive

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFV152

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFV152

1 reference

22 September 2017

1 reference