(Q40738889)

23 September 2017

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter (English)

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23 September 2017

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1

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23 September 2017

Lucilla Luzi

2

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author name string

Sonia Pacini

series ordinal

3

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23 September 2017

Cosima T Baldari

series ordinal

4

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23 September 2017

Pier Giuseppe Pelicci

series ordinal

5

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23 September 2017

language of work or name

English

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publication date

10 April 2002

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

277

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23 September 2017

22370-22376

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23 September 2017

25

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Evolution of Shc functions from nematode to human

23 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Shc signaling in differentiating neural progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

CpG islands in vertebrate genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

DNA methylation and chromatin modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Fli-1b is generated by usage of differential splicing and alternative promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Differentially expressed messenger RNA isoforms of the human estrogen receptor-alpha gene are generated by alternative splicing and promoter usage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alternative promoter usage and tissue specific expression of the mouse somatostatin receptor 2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M200280200

21 January 2018

Identifiers

DOI

10.1074/JBC.M200280200

1 reference

23 September 2017

1 reference