(Q40792701)

English

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

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24 October 2019

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation (English)

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24 October 2019

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24 October 2019

author name string

Ory K

1

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24 October 2019

Legros Y

2

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24 October 2019

Auguin C

3

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24 October 2019

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1 August 1994

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24 October 2019

The EMBO Journal

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24 October 2019

13

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24 October 2019

3496-3504

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24 October 2019

15

1 reference

Europe PubMed Central

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24 October 2019

The multistep nature of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

How many mutations are required for tumorigenesis? Implications from human cancer data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Novel DNA binding of p53 mutants and their role in transcriptional activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Monoclonal antibodies against simian virus 40 nuclear large T tumour antigen: epitope mapping, papova virus cross-reaction and cell surface staining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

A new technique for the assay of infectivity of human adenovirus 5 DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Firefly luciferase luminescence assays using scintillation counters for quantitation in transfected mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

p53 functions as a cell cycle control protein in osteosarcomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Suppression of human colorectal carcinoma cell growth by wild-type p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Structural aspects of the p53 protein in relation to gene evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

p53 mutations: gains or losses?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Wild-type p53 can down-modulate the activity of various promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

p53 mutations in human cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Wild-type p53 binds to the TATA-binding protein and represses transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

TP53 tumor suppressor gene: a model for investigating human mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Definition of a consensus binding site for p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

The clonal evolution of tumor cell populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

24 September 2017

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

25 September 2017

Biological activities of p53 mutants in Burkitt's lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

p53 mutants with changes in conserved region II: three classes with differing antibody reactivity, SV40 T antigen binding and ability to inhibit transformation of rat cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

p53 as a growth suppressor gene in HBV-related hepatocellular carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Gain of function mutations in p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

p53: a frequent target for genetic abnormalities in lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Evidence that immunological variants of p53 represent alternative protein conformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

Diversity of human p53 mutants revealed by complex formation to SV40 T antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

17 June 2018

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

19 August 2018

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=395253

19 August 2018

Screening patients for heterozygous p53 mutations using a functional assay in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different tumor-derived p53 mutants exhibit distinct biological activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of human p53 specific monoclonal antibodies and their use in immunohistochemical studies of tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant p53 proteins bind DNA abnormally in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temperature-sensitive mutants of p53 associated with human carcinoma of the lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functionally inactive p53 Li-Fraumeni syndrome mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/8062826

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1994.TB06656.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8062826%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8062826%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8062826%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

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