(Q40795252)

23 September 2017

TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway (English)

1 reference

23 September 2017

M H Nguyen

1

1 reference

23 September 2017

J M Ho

series ordinal

2

1 reference

23 September 2017

B K Beattie

series ordinal

3

1 reference

23 September 2017

D L Barber

series ordinal

4

1 reference

23 September 2017

language of work or name

English

0 references

publication date

2 July 2001

1 reference

Journal of Biological Chemistry

23 September 2017

1 reference

23 September 2017

276

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23 September 2017

32704-32713

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23 September 2017

35

1 reference

23 September 2017

Chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Role of IRS-2 in insulin and cytokine signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

A dominant negative erythropoietin (EPO) receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Oncogenes and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Akt activation by growth factors is a multiple-step process: the role of the PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

The IRS-signalling system during insulin and cytokine action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

CREB is a regulatory target for the protein kinase Akt/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Bcr - Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103100200

21 January 2018

Identifiers

DOI

10.1074/JBC.M103100200

1 reference

23 September 2017

1 reference