(Q40816577)

English

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

scientific article published on 13 February 2001

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scholarly article

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6 November 2019

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling (English)

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6 November 2019

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6 November 2019

Marketa J Zvelebil

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6 November 2019

Matthias P Wymann

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6 November 2019

author name string

Bulgarelli-Leva G

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6 November 2019

Van Obberghen E

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6 November 2019

Waterfield MD

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6 November 2019

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13 February 2001

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6 November 2019

Journal of Biological Chemistry

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6 November 2019

276

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6 November 2019

21544-21554

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6 November 2019

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6 November 2019

Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways

1 reference

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21 January 2018

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1 reference

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21 January 2018

Signaling by distinct classes of phosphoinositide 3-kinases

1 reference

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21 January 2018

Phosphoinositide kinases

1 reference

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21 January 2018

Structure and function of phosphoinositide 3-kinases.

1 reference

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21 January 2018

Using structure to define the function of phosphoinositide 3-kinase family members

1 reference

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21 January 2018

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

1 reference

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21 January 2018

Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain

1 reference

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21 January 2018

Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

1 reference

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21 January 2018

Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain

1 reference

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21 January 2018

Phosphoinositides as regulators in membrane traffic

1 reference

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21 January 2018

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1 reference

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21 January 2018

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

1 reference

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21 January 2018

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1 reference

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21 January 2018

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

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21 January 2018

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

1 reference

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21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

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21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

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21 January 2018

The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning

1 reference

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21 January 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

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21 January 2018

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1 reference

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21 January 2018

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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21 January 2018

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor

1 reference

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21 January 2018

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

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21 January 2018

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

1 reference

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21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

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21 January 2018

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M011330200

21 January 2018

ATM-related genes: what do they tell us about functions of the human gene?

1 reference

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21 January 2018

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

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21 January 2018

The production of phosphatidylinositol trisphosphate is stimulated by thrombin in human platelets

1 reference

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21 January 2018

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1 reference

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21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

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21 January 2018

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

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21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

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21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

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21 January 2018

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

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21 January 2018

STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor

1 reference

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21 January 2018

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains

1 reference

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21 January 2018

Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p

1 reference

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21 January 2018

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

1 reference

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21 January 2018

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils

1 reference

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21 January 2018

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

1 reference

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21 January 2018

Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

1 reference

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Structure of Type IIβ Phosphatidylinositol Phosphate Kinase

1 reference

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21 January 2018

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

1 reference

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21 January 2018

Lipid-Regulated Kinases: Some Common Themes at Last

1 reference

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21 January 2018

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1 reference

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21 January 2018

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

1 reference

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21 January 2018

The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity

1 reference

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21 January 2018

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

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21 January 2018

Characterization of putative polyphosphoinositide binding motifs from phospholipase C beta 2

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21 January 2018

Identifiers

10.1074/JBC.M011330200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278889%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11278889%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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