(Q40817414)

24 September 2017

1 reference

title

Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury (English)

1 reference

24 September 2017

U A Boelsterli

1

1 reference

PubMed ID

8313837

24 September 2017

language of work or name

English

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publication date

1 January 1993

1 reference

24 September 2017

Drug Metabolism Reviews

1 reference

24 September 2017

25

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24 September 2017

395-451

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24 September 2017

4

1 reference

Possible mechanism of liver necrosis caused by aromatic organic compounds

24 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Metabolic activation and drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Enzymatic activation of chemicals to toxic metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Covalent and noncovalent interactions in acute lethal cell injury caused by chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Role of Covalent and Noncovalent Interactions in Cell Toxicity: Effects on Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Update of hepatotoxicity due to classes of drugs in common clinical use: non-steroidal drugs, anti-inflammatory drugs, antibiotics, antihypertensives, and cardiac and psychotropic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Reactive intermediates and their toxicological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Halothane metabolism: Kupffer cells carry and partially process trifluoroacetylated protein adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Isolation of S-(bromophenyl)cysteine isomers from liver proteins of bromobenzene-treated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

What we have learned from phalloidin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Modulation of cocaine metabolism in primary rat hepatocyte cultures: effects on irreversible binding and protein biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Comparative cytotoxic effects of acetaminophen (N-acetyl-p-aminophenol), a non-hepatotoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Gut-derived substances in activation of hepatic macrophages after partial hepatectomy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The immunologic and metabolic basis of drug hypersensitivities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Neoantigens associated with halothane hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Drug-protein conjugation and its immunological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Drug-induced allergic hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Drug-induced allergic hepatitis: does isaxonine fall into this category?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: Isomer-specific and strain-specific differential toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Flavin-containing monooxygenases: catalytic mechanism and substrate specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Glucuronidation and its Role in Regulation of Biological Activity of Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Irreversible binding of zomepirac to plasma protein in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Disposition and irreversible plasma protein binding of tolmetin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The molecular basis of halothane-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Drug-protein conjugates--V. Sex-linked differences in the metabolism and irreversible binding of 17 alpha-ethinylestradiol in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Presence of covalently bound metabolites on rat hepatocyte plasma membrane proteins after administration of isaxonine, a drug leading to immunoallergic hepatitis in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Estimation of exposure of man to substances reacting covalently with macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Structure-activity studies on organoselenium alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Alkylation of the liver plasma membrane and inhibition of the Ca2+ ATPase by acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Effects of modifying structure on electrophilic reactions with biological nucleophiles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Acetaminophen hepatotoxicity: correspondence of selective protein arylation in human and mouse liver in vitro, in culture, and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The acylation of proteins by xenobiotic amphipathic carboxylic acids in cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Microsomal target proteins of metabolically activated aromatic hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The calcium-binding protein calreticulin is covalently modified in rat liver by a reactive metabolite of the inhalation anesthetic halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Hypothesis: alcoholic liver injury and the covalent binding of acetaldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Mechanism-based irreversible enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Inhibitors of Cytochrome P-450s and their mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Suicidal destruction of cytochrome P-450 during oxidative drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The mechanism of bioactivation and antigen formation of amodiaquine in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Metabolic Activation of Haloalkanes and Testsin vitrofor Mutagenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Ethanol-induced enhancement of cocaine bioactivation and irreversible protein binding: evidence against a role of cytochrome P-450IIE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The role of biliary excretion in the hepatotoxicity of furosemide in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Metabolic activation of the antidepressant tianeptine. II. In vivo covalent binding and toxicological studies at sublethal doses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

Inactivation of rat hepatic cytochrome P-450 by spironolactone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539308993981

10.3109/03602539308993981

21 January 2018

Identifiers

DOI

1 reference

24 September 2017

1 reference

PubMed ID

8313837