Wikidata

(Q408179)

English

SMAD family member 4

mammalian protein found in Homo sapiens

  • SMAD 4
  • SMAD, mothers against DPP homolog 4
  • deleted in pancreatic carcinoma locus 4
  • SMAD4
  • mothers against decapentaplegic homolog 4
  • deletion target in pancreatic carcinoma 4
  • mothers against decapentaplegic, Drosophila, homolog of, 4
  • MAD homolog 4
  • hSMAD4
  • Smad4 Protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
46 references
retrieved
9 May 2019
stated in
Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
TIF1gamma controls erythroid cell fate by regulating transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
The protein interaction landscape of the human CMGC kinase group
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Charting the molecular links between driver and susceptibility genes in colorectal cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis of heteromeric smad protein assembly in TGF-beta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Pooled-matrix protein interaction screens using Barcode Fusion Genetics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis of Smad1 activation by receptor kinase phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
A Novel E1A-like Inhibitor of Differentiation (EID) Family Member, EID-2, Suppresses Transforming Growth Factor (TGF)-β Signaling by Blocking TGF-β-induced Formation of Smad3-Smad4 Complexes
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
retrieved
9 May 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IPI
cell component
nucleus
determination method
IEA
IDA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IEA
retrieved
9 May 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
biological process
positive regulation of transcription, DNA-templated
determination method
IEA
IDA
6 references
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IEA
retrieved
9 May 2019
stated in
Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
transforming growth factor beta receptor signaling pathway
determination method
IDA
IEA
IMP
ISS
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
ISS
retrieved
9 May 2019
stated in
Pokemon (FBI-1) interacts with Smad4 to repress TGF-β-induced transcriptional responses
GOA
curator
UniProt
UniProt protein ID
Q13485
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IEA
retrieved
9 May 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
retrieved
9 May 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13485
determination method
IDA
Gene Atlas image
PBB GE SMAD4 202527 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D051901
subject named as
Smad4 Protein
0 references
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q408179&oldid=2022900946"