(Q40822748)

24 September 2017

Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer (English)

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24 September 2017

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N Burri

1

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24 September 2017

P Shaw

2

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24 September 2017

H Bouzourene

3

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24 September 2017

I Sordat

4

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24 September 2017

B Sordat

5

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24 September 2017

M Gillet

6

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24 September 2017

D Schorderet

7

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24 September 2017

F T Bosman

8

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24 September 2017

P Chaubert

9

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24 September 2017

1 February 2001

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24 September 2017

Laboratory Investigation

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24 September 2017

81

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24 September 2017

217-229

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24 September 2017

2

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https://scigraph.springernature.com/pub.10.1038/labinvest.3780230

24 September 2017

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cites work

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Sp1 elements protect a CpG island from de novo methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

High sensitivity mapping of methylated cytosines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

A cell cycle regulator potentially involved in genesis of many tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

DNA methylation differences associated with tumor tissues identified by genome scanning analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mutations and altered expression of p16INK4 in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

P16 gene in uncultured tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

Complex methylation patterns analyzed by single-strand conformation polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

p53 gene point mutations in relation to p53 nuclear protein accumulation in colorectal cancers

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3780230

7 January 2021

10.1038/LABINVEST.3780230

Identifiers

DOI

1 reference

24 September 2017

1 reference