(Q40845372)

24 September 2017

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism (English)

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24 September 2017

P Wei

1

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24 September 2017

J Zhang

2

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24 September 2017

M Egan-Hafley

3

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24 September 2017

S Liang

4

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24 September 2017

D D Moore

5

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24 September 2017

language of work or name

English

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publication date

1 October 2000

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24 September 2017

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24 September 2017

407

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24 September 2017

920-923

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24 September 2017

6806

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https://scigraph.springernature.com/pub.10.1038/35038112

24 September 2017

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cites work

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

1 reference

7 January 2021

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

1 reference

7 January 2021

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

7 January 2021

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

7 January 2021

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

7 January 2021

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

1 reference

7 January 2021

Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone

1 reference

7 January 2021

Effect of cytochrome P450 inducers on cocaine-mediated hepatotoxicity

1 reference

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

7 January 2021

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

7 January 2021

Hepatotoxicity of psychotropic drugs

1 reference

7 January 2021

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

1 reference

7 January 2021

Identifiers

DOI

10.1038/35038112

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Dimensions Publication ID

24 September 2017

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