(Q40856599)

24 September 2017

title

Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds (English)

1 reference

24 September 2017

1 reference

Fujiki H

1

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24 September 2017

Suganuma M

series ordinal

2

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24 September 2017

publication date

1 January 1993

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Advances in Cancer Research

24 September 2017

language of work or name

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24 September 2017

volume

61

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24 September 2017

page(s)

143-194

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publication type of scholarly work

24 September 2017

review article

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Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions

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Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

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Tumor necrosis, cachexia, shock, and inflammation: a common mediator

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Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

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7 January 2021

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

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7 January 2021

The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa

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7 January 2021

Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction

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7 January 2021

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

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7 January 2021

Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells

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Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae).

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7 January 2021

Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand

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7 January 2021

Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts

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7 January 2021

A new antibiotic, tautomycin

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7 January 2021

Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin

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7 January 2021

The structure and regulation of protein phosphatases

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7 January 2021

Specific labeling of mouse brain membrane phospholipids with [20-3H]phorbol 12-p-azidobenzoate 13-benzoate, a photolabile phorbol ester

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7 January 2021

Regulation of progesterone receptor-mediated transcription by phosphorylation

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7 January 2021

Effect of okadaic acid on phosphorylation-dephosphorylation of myosin light chain in aortic smooth muscle homogenate

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7 January 2021

Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin

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7 January 2021

Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases

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7 January 2021

Cytoskeletal integrity in interphase cells requires protein phosphatase activity

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7 January 2021

Evidence of liver damage by toxin from a bloom of the blue‐green alga, Microcystis aeruginosa

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Poisonous Australian Lake

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7 January 2021

Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?

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7 January 2021

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Induction of ornithine decarboxylase activity in mouse skin by a possible tumor promoter, okadaic acid

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Mechanisms of action of okadaic acid class tumor promoters on mouse skin

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Dual regulation of intermediate filament phosphorylation

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Diaplacental initiation of NMRI mice with 7,12-dimethylbenz[a]anthracene during gestation days 6--20 and postnatal treatment of the F1-generation with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate: tumor incidence in organs other than the s

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Analysis and purification of toxic peptides from cyanobacteria by reversed-phase high-performance liquid chromatography

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Structural determination of geometrical isomers of microcystins LR and RR from cyanobacteria by two-dimensional NMR spectroscopic techniques

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Activity of diverse tumor promoters in a keratinocyte co-culture model of initiated epidermis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid induces the expression of both early and secondary response genes in mouse keratinocytes

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Vimentin, a cytoskeletal substrate of protein kinase C

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx

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7 January 2021

Bioactive marine metabolites. 24. Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyx

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid and phorbol esters: comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Phosphorylation of nuclear protein is an early event in TGFβ1 action

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Production of antibodies and development of a radioimmunoassay for okadaic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Tautomycin from the bacterium Streptomyces verticillatus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyx

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

When worlds collide: immunosuppressants meet protein phosphatases

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Permeability of a non-TPA-type tumor promoter, okadaic acid, through lipid bilayer membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Identification of 12 hepatotoxins from a Homer Lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Structure-activity relationship within a series of okadaic acid derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Photoaffinity labeling of protein phosphatase 2A, the receptor for a tumor promoter okadaic acid, by [27-3H]methyl 7-O-(4-azidobenzoyl)okadaate

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Rapid purification of protein phosphatase 2A from mouse brain by microcystin-affinity chromatography

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Structure-Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

The role of protein kinase C in cell surface signal transduction and tumour promotion

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Phosphorylation of intermediate filament proteins by cAMP-dependent protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid and dinophysistoxin-1, non-TPA-type tumor promoters, stimulate prostaglandin E2 production in rat peritoneal macrophages

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid is a potent angiogenesis inducer

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Effects of okadaic acid on mouse hemopoietic cells

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7 January 2021

Tumor necrosis factor (TNF).

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7 January 2021

How does interleukin 1 activate cells? Interleukin 1 signal transduction

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7 January 2021

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

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7 January 2021

Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta

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7 January 2021

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Regulation of gene expression by tumor promoters

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Nodularin, microcystin, and the configuration of Adda

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Characterization of chemically tritiated microcystin-LR and its distribution in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Promotion of BALB/3T3 cell transformation by the okadaic acid class of tumor promoters, okadaic acid and dinophysistoxin-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Flat reversion by okadaic acid of raf and ret-II transformants

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Apparent "activation" of protein kinases by okadaic acid class tumor promoters

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Molecular cloning and expression of a receptor for human tumor necrosis factor

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Phospholipids involved in specific binding of 12-O-(5-azido-2-nitrobenzoyl)phorbol-13-acetate to epidermal microsomes, a photolabeling study

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Molecular and cellular biology of intermediate filaments

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Tumor promoting activity of teleocidin in skin and forestomach of mice initiated transplacentally with 7,12-dimethylbenz(a)anthracene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Specific binding of okadaic acid, a new tumor promoter in mouse skin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

An alternative theory of tissue specificity by tumor promotion of okadaic acid in glandular stomach of SD rats

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Preparation of monoclonal antibodies against okadaic acid prepared from the sponge Halichondria okadai

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Allelotype of colorectal carcinomas

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https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Association of protein phosphatase 2A with polyoma virus medium tumor antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Toxins contained in Microcystis species of cyanobacteria (blue-green algae).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Diarrhetic shellfish toxins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Binding competition of okadaic acid derivatives to anti-okadaic acid antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960958-6

7 January 2021

10.1016/S0065-230X(08)60958-6

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