(Q41073233)

26 September 2017

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title

Molecular basis of polymorphic drug metabolism (English)

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26 September 2017

A K Daly

1

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26 September 2017

1 November 1995

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Journal of Molecular Medicine

26 September 2017

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26 September 2017

73

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26 September 2017

539-553

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26 September 2017

11

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https://scigraph.springernature.com/pub.10.1007/bf00195139

26 September 2017

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cites work

Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.

1 reference

12 December 2020

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1 reference

12 December 2020

Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type I

1 reference

12 December 2020

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe

1 reference

12 December 2020

Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans

1 reference

12 December 2020

A missense mutation in exon 6 of the CYP2D6 gene leading to a histidine 324 to proline exchange is associated with the poor metabolizer phenotype of sparteine

1 reference

12 December 2020

Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

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12 December 2020

Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus

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12 December 2020

Genetic polymorphism for human platelet thermostable phenol sulfotransferase (TS PST) activity

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12 December 2020

Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population

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12 December 2020

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

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12 December 2020

Beneficial effects of conversion from cyclosporin to azathioprine after kidney transplantation

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12 December 2020

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

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12 December 2020

The clinical pharmacology of 6-mercaptopurine

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12 December 2020

Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility.

1 reference

12 December 2020

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

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12 December 2020

Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer

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12 December 2020

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

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12 December 2020

An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin

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12 December 2020

Human liver estrogen sulfotransferase: identification by cDNA cloning and expression

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12 December 2020

Glutathione S-transferase and epoxide hydrolase activity in human leukocytes in relation to risk of lung cancer and other smoking-related cancers

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12 December 2020

Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype

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12 December 2020

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase

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12 December 2020

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes

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12 December 2020

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

1 reference

12 December 2020

Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon

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12 December 2020

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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12 December 2020

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences

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12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

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12 December 2020

Genetic heterogeneity of the human glutathione transferases: a complex of gene families

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12 December 2020

Racial and gender differences in N-acetyltransferase, xanthine oxidase, and CYP1A2 activities

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene

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12 December 2020

Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity

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12 December 2020

Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.

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12 December 2020

An efficient strategy for detection of known and new mutations of the CYP2D6 gene using single strand conformation polymorphism analysis

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12 December 2020

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12 December 2020

A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).

1 reference

12 December 2020

Dihydropyrimidine dehydrogenase deficiency leading to thymine-uraciluria. An inborn error of pyrimidine metabolism

1 reference

12 December 2020

A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer

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12 December 2020

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA

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12 December 2020

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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12 December 2020

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

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12 December 2020

Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility

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12 December 2020

Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization

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12 December 2020

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6

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12 December 2020

Molybdenum hydroxylases as drug-metabolizing enzymes

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12 December 2020

Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form

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12 December 2020

Genetic Linkage of Lung Cancer-Associated MspI Polymorphisms with Amino Acid Replacement in the Heme Binding Region of the Human Cytochrome P450IA1 Gene1

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12 December 2020

Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9

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12 December 2020

A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase

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12 December 2020

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

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12 December 2020

Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1.

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12 December 2020

Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosis

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12 December 2020

Glutathione transferases--structure and catalytic activity

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12 December 2020

Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study.

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12 December 2020

Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation

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12 December 2020

Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2

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12 December 2020

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

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12 December 2020

Human liver dehydroepiandrosterone sulfotransferase: nature and extent of individual variation

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12 December 2020

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy

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12 December 2020

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

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12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

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12 December 2020

The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma

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12 December 2020

Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese

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12 December 2020

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

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12 December 2020

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

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12 December 2020

Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine

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12 December 2020

Phenytoin: pharmacogenetic polymorphism of 4'-hydroxylation

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12 December 2020

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

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12 December 2020

Biochemistry and genetics of monoamine oxidase

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12 December 2020

Polymorphic forms of the Ah receptor and induction of the CYP1A1 gene

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12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

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12 December 2020

Methyltransferase pharmacogenetics

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12 December 2020

Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis

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12 December 2020

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles

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12 December 2020

Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood

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12 December 2020

Primary structures and properties of two related forms of aryl sulfotransferases in human liver

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12 December 2020

Molecular characterisation of a human aryl sulfotransferase cDNA

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12 December 2020

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

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12 December 2020

Cytochrome P450IIE1 genetic polymorphisms, racial variation, and lung cancer risk

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12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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12 December 2020

Patient-controlled analgesia (PCA) with codeine for postoperative pain relief in ten extensive metabolisers and one poor metaboliser of dextromethorphan

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12 December 2020

Paradoxical relationship between acetylator phenotype and amonafide toxicity

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12 December 2020

Genotype and phenotype of glutathione S-transferase class mu isoenzymes mu and psi in lung cancer patients and controls

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12 December 2020

Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient

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12 December 2020

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

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12 December 2020

The role of individual human cytochromes P450 in drug metabolism and clinical response

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12 December 2020

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome

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12 December 2020

Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population

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12 December 2020

Caffeine as a metabolic probe: a comparison of the metabolic ratios used to assess CYP1A2 activity

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12 December 2020

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.

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12 December 2020

Nomenclature for N-acetyltransferases

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12 December 2020

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site

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12 December 2020

Tolbutamide hydroxylation in humans: lack of bimodality in 106 healthy subjects

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12 December 2020

Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity

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12 December 2020

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

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12 December 2020

Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms

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12 December 2020

Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine

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12 December 2020

Sulfotransferase pharmacogenetics

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12 December 2020

Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls

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12 December 2020

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors

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12 December 2020

Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.

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12 December 2020

Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activity

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12 December 2020

Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population

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12 December 2020

Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone

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12 December 2020

Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.

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12 December 2020

Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer.

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12 December 2020

A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine

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12 December 2020

Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase

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12 December 2020

A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype

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12 December 2020

Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe

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12 December 2020

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.

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12 December 2020

Identification of the “major” polymorphic carbocysteine metabolite as S-(carboxymethylthio)-l-cysteine

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12 December 2020

Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells

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12 December 2020

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

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12 December 2020

Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.

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12 December 2020

Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions

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12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

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12 December 2020

Pharmacogenetics of tolbutamide metabolism in humans

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12 December 2020

Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

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12 December 2020

The human serum paraoxonase/arylesterase polymorphism

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12 December 2020

Interindividual variability of coumarin 7-hydroxylation in healthy volunteers

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12 December 2020

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers

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12 December 2020

An XmnI RFLP detected with a probe for the CYP2E gene locus on chromosome 10.

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12 December 2020

Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA

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12 December 2020

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

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12 December 2020

Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver

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12 December 2020

Variation in human metabolism of S-carboxymethylcysteine

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12 December 2020

Interindividual variability in the N-sulphation of desipramine in human liver and platelets

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12 December 2020

Metabolic polymorphisms

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12 December 2020

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

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12 December 2020

GST1 gene deletion determined by polymerase chain reaction

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12 December 2020

The molecular basis of the human serum paraoxonase activity polymorphism.

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12 December 2020

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

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12 December 2020

Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer

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12 December 2020

Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities

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12 December 2020

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

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12 December 2020

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

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12 December 2020

Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure.

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

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12 December 2020

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test

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12 December 2020

Polymorphic hydroxylation of Debrisoquine in man.

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12 December 2020

Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines

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12 December 2020

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

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12 December 2020

Genetically variable metabolism of antidepressants and neuroleptic drugs in man.

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12 December 2020

Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.

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12 December 2020

Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities

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12 December 2020

Human glutathione S-transferase mu (GST mu) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers.

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12 December 2020

Deficient metabolism of debrisoquine and sparteine

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12 December 2020

cDNA and amino acid sequences of two members of the human P450IIC gene subfamily

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12 December 2020

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

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12 December 2020

UDP-glucuronosyltransferases

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12 December 2020

The molecular biology of the flavin-containing monooxygenases of man

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12 December 2020

Genetic polymorphism of S-mephenytoin hydroxylation

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12 December 2020

Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient

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12 December 2020

Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I

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12 December 2020

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene

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12 December 2020

Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.

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12 December 2020

Pharmacogenetics of alcohol metabolism and alcoholism

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

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12 December 2020

Lack of a genetic polymorphism in the glucuronidation of fenofibric acid

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12 December 2020

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes

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12 December 2020

Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.

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12 December 2020

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

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12 December 2020

DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers

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12 December 2020

The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes

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12 December 2020

The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung

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12 December 2020

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

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12 December 2020

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

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12 December 2020

Potential importance of dihydropyrimidine dehydrogenase (DPD) in cancer chemotherapy.

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12 December 2020

Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form

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12 December 2020

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

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12 December 2020

Variability of acetaminophen metabolism in Caucasians and Orientals

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12 December 2020

Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro

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12 December 2020

The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein

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12 December 2020

Urinary glucuronide excretion of fenofibric and clofibric acid glucuronides in man. Is it polymorphic?

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12 December 2020

Genetic polymorphism of trimethylamine N-oxidation

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12 December 2020

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10

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12 December 2020

A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype

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12 December 2020

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

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12 December 2020

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

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12 December 2020

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

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12 December 2020

Polymorphisms of human Ah receptor gene are not involved in lung cancer

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12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

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12 December 2020

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

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12 December 2020

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

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12 December 2020

Identification of two human brain aryl sulfotransferase cDNAs

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12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

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12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

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12 December 2020

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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12 December 2020

Mutant debrisoquine hydroxylation genes in Parkinson's disease

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12 December 2020

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient

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12 December 2020

Mspl polymorphism of the human CYP2E gene

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12 December 2020

Drug glucuronidation in humans

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12 December 2020

Genetic and environmental factors that regulate cytosolic epoxide hydrolase activity in normal human lymphocytes

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12 December 2020

Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene

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12 December 2020

Identifiers

DOI

10.1007/BF00195139

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26 September 2017

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PubMed ID

8751138