(Q411529)

English

Interleukin 1 beta

mammalian protein found in Homo sapiens

IL-1 beta
catabolin
IL1B
interleukin 1beta
pro-interleukin-1-beta
preinterleukin 1 beta
interleukin-1 beta
IL-1beta
pro-IL-1beta
IL-1β
pro-interleukin-1β
Pro–IL-1β

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

13 November 2019

UniProt protein ID

interleukin-1 beta

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01584

Cytokine IL1/FGF

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01584

interleukin-1 family

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Interleukin-1 propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Interleukin-1 conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

9ilb.jpg
1,000 × 797; 204 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein domain specific binding

determination method or standard

1 reference

8 April 2019

The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

interleukin-1 receptor binding

determination method or standard

3 references

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

cytokine activity

determination method or standard

5 references

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

cytokine activity

determination method or standard

6 references

1 January 2018

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

integrin binding

determination method or standard

1 reference

8 April 2019

Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

protein binding

determination method or standard

1 reference

8 April 2019

PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

extracellular region

determination method or standard

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

secretory granule

determination method or standard

1 reference

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

extracellular space

determination method or standard

5 references

23 May 2017

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

extracellular space

determination method or standard

6 references

8 April 2019

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

biological process

positive regulation of protein phosphorylation

determination method or standard

2 references

8 April 2019

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

smooth muscle adaptation

determination method or standard

1 reference

8 April 2019

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of calcidiol 1-monooxygenase activity

determination method or standard

cellular response to mechanical stimulus

determination method or standard

1 reference

8 April 2019

Expression of the Bcl-2 protein BAD promotes prostate cancer growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of interleukin-8 production

determination method or standard

1 reference

8 April 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of mitotic nuclear division

determination method or standard

1 reference

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

response to carbohydrate

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

embryo implantation

determination method or standard

1 reference

8 April 2019

Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

apoptotic process

determination method or standard

1 reference

8 April 2019

Cytokine-induced neutrophil-mediated injury of human endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

cellular response to organic substance

determination method or standard

1 reference

8 April 2019

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of phagocytosis

determination method or standard

1 reference

8 April 2019

Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

regulation of insulin secretion

determination method or standard

1 reference

8 April 2019

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

neutrophil chemotaxis

determination method or standard

1 reference

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of protein export from nucleus

determination method or standard

1 reference

8 April 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of myosin light chain kinase activity

determination method or standard

1 reference

8 April 2019

Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of T cell proliferation

determination method or standard

1 reference

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

inflammatory response

determination method or standard

5 references

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

sequestering of triglyceride

determination method or standard

1 reference

8 April 2019

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

hyaluronan biosynthetic process

determination method or standard

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of heterotypic cell-cell adhesion

determination method or standard

cellular response to organic cyclic compound

determination method or standard

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of DNA-binding transcription factor activity

determination method or standard

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

14 January 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01584&geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

positive regulation of granulocyte macrophage colony-stimulating factor production

determination method or standard

1 reference

8 April 2019

Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

immune response

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

ectopic germ cell programmed cell death

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

leukocyte migration

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

lipopolysaccharide-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of vascular endothelial growth factor receptor signaling pathway

determination method or standard

1 reference

8 April 2019

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of cell adhesion molecule production

determination method or standard

1 reference

8 April 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

response to ATP

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

monocyte aggregation

determination method or standard

1 reference

8 April 2019

BMP-7 modulates hyaluronan-mediated proximal tubular cell-monocyte interaction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

protein kinase B signaling

determination method or standard

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of nitric oxide biosynthetic process

determination method or standard

1 reference

8 April 2019

Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

cell-cell signaling

determination method or standard

1 reference

8 April 2019

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of monocyte chemotactic protein-1 production

determination method or standard

1 reference

8 April 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of membrane protein ectodomain proteolysis

determination method or standard

1 reference

8 April 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of interferon-gamma production

determination method or standard

determination method or standard

1 reference

8 April 2019

Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of histone acetylation

determination method or standard

1 reference

8 April 2019

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of gene expression

determination method or standard

4 references

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

The microRNA-29 family in cartilage homeostasis and osteoarthritis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

interleukin-1 beta production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of T cell mediated immunity

determination method or standard

1 reference

8 April 2019

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

extrinsic apoptotic signaling pathway in absence of ligand

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

positive regulation of vascular endothelial growth factor production

determination method or standard

3 references

23 May 2017

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

23 May 2017

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method or standard

1 reference

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

negative regulation of lipid catabolic process

determination method or standard

1 reference

8 April 2019

Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

regulation of establishment of endothelial barrier

determination method or standard

1 reference

8 April 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of cell division

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

23 May 2017

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

regulation of defense response to virus by host

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of JNK cascade

determination method or standard

1 reference

23 May 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01584

determination method or standard

fever generation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of vascular endothelial growth factor production

determination method or standard

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of gene expression

determination method or standard

5 references

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

The microRNA-29 family in cartilage homeostasis and osteoarthritis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of epithelial to mesenchymal transition

determination method or standard

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

8 April 2019

IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

interleukin-6 production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of interleukin-6 production

determination method or standard

3 references

1 January 2018

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard

positive regulation of angiogenesis

determination method or standard

4 references

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01584

determination method or standard