(Q41474990)

13 June 2018

title

A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells (English)

1 reference

13 June 2018

author name string

H Ogasawara

1

1 reference

13 June 2018

K Nishio

2

1 reference

13 June 2018

Y Takeda

3

1 reference

13 June 2018

T Ohmori

4

1 reference

13 June 2018

N Kubota

5

1 reference

13 June 2018

Y Funayama

6

1 reference

13 June 2018

T Ohira

7

1 reference

13 June 2018

Y Kuraishi

8

1 reference

13 June 2018

Y Isogai

9

1 reference

13 June 2018

N Saijo

10

1 reference

13 June 2018

publication date

1 April 1994

1 reference

13 June 2018

number of pages

8

1 reference

Japanese Journal of Cancer Research

inferred from page(s)

published in

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13 June 2018

volume

85

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13 June 2018

page(s)

418-425

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13 June 2018

issue

4

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13 June 2018

Mechanism of interaction of CC-1065 (NSC 298223) with DNA.

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Rhizoxin, a macrocyclic lactone antibiotic, as a new antitumor agent against human and murine tumor cells and their vincristine-resistant sublines

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Adozelesin, a selected lead among cyclopropylpyrroloindole analogs of the DNA-binding antibiotic, CC-1065.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

DNA damage and differential cytotoxicity produced in human carcinoma cells by CC-1065 analogues, U-73,975 and U-77,779

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Cytotoxicity and antitumor activity of carzelesin, a prodrug cyclopropylpyrroloindole analogue.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Promotion of microtubule assembly in vitro by taxol

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

Anticellular and antitumor activity of duocarmycins, novel antitumor antibiotics

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919473

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer

3 July 2018

1 reference

12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity

1 reference

12 December 2020

Effects of U-71,184 and several other CC-1065 analogues on cell survival and cell cycle of Chinese hamster ovary cells

1 reference

12 December 2020

CC-1065 (NSC 298223), a novel antitumor agent that interacts strongly with double-stranded DNA

1 reference

12 December 2020

Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment

1 reference

12 December 2020

Effect of the (+)-CC-1065-(N3-adenine)DNA adduct on in vitro DNA synthesis mediated by Escherichia coli DNA polymerase

1 reference

12 December 2020

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

12 December 2020

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

1 reference

12 December 2020

Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity

1 reference

12 December 2020

10.1111/J.1349-7006.1994.TB02375.X

Identifiers

DOI

1 reference

13 June 2018

PMCID

5919473

1 reference

13 June 2018

PubMed ID

8200853

1 reference

13 June 2018