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The complexity of signaling pathways activated by the BCR.
scientific article published on June 1997
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
review article
1 reference
stated in
Europe PubMed Central
title
The complexity of signaling pathways activated by the BCR.
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
author name string
DeFranco AL
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
publication date
1 June 1997
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
published in
Current Opinion in Immunology
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
volume
9
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
page(s)
296-308
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
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Protein tyrosine kinases in the initiation of antigen receptor signaling
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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
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Transmembrane signaling by antigen receptors of B and T lymphocytes
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Regulation of antigen receptor signal transduction by protein tyrosine kinases
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Protein modules and signalling networks
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7 January 2021
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Signalling by receptor tyrosine kinases
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7 January 2021
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Recognition and specificity in protein tyrosine kinase-mediated signalling
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B lymphocyte receptors and polyphosphoinositide degradation
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Murine CD38: an immunoregulatory ectoenzyme.
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Structure and function of the B cell antigen receptor
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Elevation of cytosolic calcium is sufficient to induce growth inhibition in a B cell lymphoma
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Immunodeficiency in protein kinase cbeta-deficient mice
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7 January 2021
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Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes
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7 January 2021
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Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation.
1 reference
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7 January 2021
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Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling
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Crossref
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Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.
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The mechanism of action of cyclosporin A and FK506
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7 January 2021
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Cyclosporin-A sensitive induction of NF-AT in murine B cells
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Crossref
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7 January 2021
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Cyclosporin A and FK506 inhibit activation-induced cell death in the murine WEHI-231 B cell line
1 reference
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Crossref
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7 January 2021
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Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes
1 reference
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Crossref
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7 January 2021
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A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation
1 reference
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Crossref
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7 January 2021
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Hyperresponsive B cells in CD22-deficient mice
1 reference
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Crossref
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7 January 2021
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CD22 regulates thymus-independent responses and the lifespan of B cells.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes
1 reference
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Crossref
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7 January 2021
based on heuristic
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1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
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1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
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7 January 2021
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1 reference
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7 January 2021
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1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of transcription by MAP kinase cascades
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction in T lymphocytes using a conditional allele of Sos
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro characterization of major ligands for Src homology 2 domains derived from protein tyrosine kinases, from the adaptor protein SHC and from GTPase-activating protein in Ramos B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine phosphorylation of Shc is mediated through Lyn and Syk in B cell receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of Shc with Grb2 regulates association of Grb2 with mSOS
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interactions between Ras proteins and their effectors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association between GTPase activators for Rho and Ras families.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative signaling via FcgammaRIIB1 in B cells blocks phospholipase Cgamma2 tyrosine phosphorylation but not Syk or Lyn activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Complex complexes: signaling at the TCR.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vav: function and regulation in hematopoietic cell signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sounding the alarm: protein kinase cascades activated by stress and inflammation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
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inferred from DOI database lookup
Activation of AP-1 in primary B lymphocytes by surface immunoglobulin requires de novo Jun-B synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A functional T-cell receptor signaling pathway is required for p95vav activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional regulation of the IL-2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C3d of complement as a molecular adjuvant: bridging innate and acquired immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle-specific induction of Cdk2 expression in B lymphocytes following antigen receptor cross-linking
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0952-7915%2897%2980074-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0952-7915(97)80074-X
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
PubMed ID
9203421
1 reference
stated in
Europe PubMed Central
PubMed ID
9203421
retrieved
2 October 2017
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