Wikidata

(Q423628)

English

FYN proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

  • src-like kinase
  • FYN oncogene related to SRC, FGR, YES
  • tyrosine-protein kinase Fyn
  • SLK
  • OKT3-induced calcium influx regulator
  • c-syn protooncogene
  • FYN
  • tyrosine kinase p59fyn(T)
  • p59-Fyn
  • proto-oncogene Syn
  • proto-oncogene c-Fyn
  • src/yes-related novel
In more languages

Statements

molecular function
protein binding
determination method
IPI
45 references
retrieved
8 April 2019
stated in
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Tau interacts with src-family non-receptor tyrosine kinases
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of FynT function by dual domain docking on PAG/Cbp
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
EG-1 interacts with c-Src and activates its signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
protein tyrosine kinase activity
determination method
IEA
EXP
TAS
IMP
15 references
retrieved
14 February 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
TAS
retrieved
14 February 2017
stated in
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
TAS
retrieved
14 February 2017
stated in
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IMP
retrieved
14 February 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Vav2 is required for cell spreading
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IEA
IMP
ISS
TAS
15 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
ISS
retrieved
8 April 2019
stated in
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Vav2 is required for cell spreading
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
cell component
biological process