Wikidata

(Q423628)

English

FYN proto-oncogene, Src family tyrosine kinase

mammalian protein found in Homo sapiens

  • src-like kinase
  • FYN oncogene related to SRC, FGR, YES
  • tyrosine-protein kinase Fyn
  • SLK
  • OKT3-induced calcium influx regulator
  • c-syn protooncogene
  • FYN
  • tyrosine kinase p59fyn(T)
  • p59-Fyn
  • proto-oncogene Syn
  • proto-oncogene c-Fyn
  • src/yes-related novel
In more languages

Statements

molecular function
protein binding
determination method
IPI
45 references
retrieved
8 April 2019
stated in
ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Tau interacts with src-family non-receptor tyrosine kinases
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of FynT function by dual domain docking on PAG/Cbp
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
EG-1 interacts with c-Src and activates its signaling pathway
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn
UniProt-GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
retrieved
8 April 2019
stated in
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process
UniProt-GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IPI
protein tyrosine kinase activity
determination method
IEA
EXP
TAS
IMP
15 references
retrieved
14 February 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
TAS
retrieved
14 February 2017
stated in
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
TAS
retrieved
14 February 2017
stated in
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IMP
retrieved
14 February 2017
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
UniProt-GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
IEA
retrieved
14 February 2017
stated in
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Vav2 is required for cell spreading
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
retrieved
14 February 2017
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06241
determination method
EXP
protein tyrosine kinase activity
determination method
EXP
IEA
IMP
ISS
TAS
15 references
retrieved
8 April 2019
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Roles of tau protein in health and disease
UniProt-GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
UniProt-GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
TAS
retrieved
8 April 2019
stated in
Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems
UniProt-GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
ISS
retrieved
8 April 2019
stated in
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IMP
retrieved
8 April 2019
stated in
UniProt-GOA
curator
UniProt
UniProt protein ID
P06241
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
UniProt-GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
IEA
retrieved
8 April 2019
stated in
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Vav2 is required for cell spreading
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
retrieved
8 April 2019
stated in
Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06241
determination method
EXP
cell component
biological process