(Q42450372)

English

v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts

scientific article published on 18 September 2003

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scholarly article

1 reference

Europe PubMed Central

31 October 2017

v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts (English)

1 reference

Europe PubMed Central

31 October 2017

0 references

author name string

Konstadinos Moissoglu

1

1 reference

Europe PubMed Central

31 October 2017

Irwin H Gelman

2

1 reference

Europe PubMed Central

31 October 2017

language of work or name

0 references

publication date

18 September 2003

1 reference

Europe PubMed Central

31 October 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

31 October 2017

278

1 reference

Europe PubMed Central

31 October 2017

47946-47959

1 reference

Europe PubMed Central

31 October 2017

48

1 reference

Europe PubMed Central

31 October 2017

Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Signaling through focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Differential signaling by the focal adhesion kinase and cell adhesion kinase beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Rho GTPases: signaling, migration, and invasion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Cell transformation by the viral src oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Ras-independent transformation by v-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Phosphorylation of p125FAK and paxillin focal adhesion proteins in src-transformed cells with different metastatic capacity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

SSeCKS, a major protein kinase C substrate with tumor suppressor activity, regulates G(1)-->S progression by controlling the expression and cellular compartmentalization of cyclin D.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Stable suppression of gene expression by RNAi in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Regulation, substrates and functions of src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Integrin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

FAK integrates growth-factor and integrin signals to promote cell migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Regulation of the cell cycle by focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Genetic alterations in prostate cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302720200

21 January 2018

Identifiers

10.1074/JBC.M302720200

1 reference

Europe PubMed Central

31 October 2017

1 reference

Europe PubMed Central

31 October 2017

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