(Q42503036)

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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level

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scholarly article

1 reference

Europe PubMed Central

1 November 2017

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level (English)

1 reference

Europe PubMed Central

1 November 2017

0 references

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1 reference

ChEBI release 2020-05-28

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based on heuristic

inferred from title

author name string

C Alarcon

1

1 reference

Europe PubMed Central

1 November 2017

B Wicksteed

2

1 reference

Europe PubMed Central

1 November 2017

C J Rhodes

3

1 reference

Europe PubMed Central

1 November 2017

publication date

20 October 2006

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

49

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Europe PubMed Central

1 November 2017

2920-2929

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Europe PubMed Central

1 November 2017

12

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Europe PubMed Central

1 November 2017

https://scigraph.springernature.com/pub.10.1007/s00125-006-0433-y

0 references

Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0433-Y

21 January 2018

Stimulation of H-3-leucine incorporation into the proinsulin and insulin fraction of isolated pancreatic mouse islets in the presence of glucagon, theophylline and cyclic AMP.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0433-Y

21 January 2018

The sulphonylurea receptor may be an ATP-sensitive potassium channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of sulfonylureas with pancreatic beta-cells. A study with glyburide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct properties of the cAMP-responsive element of the rat insulin I gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exenatide (Byetta) for type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical aspects of islet B-cell function in non-insulin-dependent diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic strategies based on glucagon-like peptide 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of tolbutamide and glibenclamide on the incorporation of [3 H]leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophysiology of the pancreatic beta-cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history of beta-cell dysfunction in NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of some modifiers of insulin secretion on insulin biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17053883

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-006-0433-Y

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

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