(Q42540536)

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Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity

scientific article published on 26 June 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

2 November 2017

Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity (English)

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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Roland Lang

7

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Christoph Hölscher

8

object named as

Christoph Hölscher

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

author name string

Tanja Schreiber

1

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Stefan Ehlers

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Lisa Heitmann

3

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Alexandra Rausch

4

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Jörg Mages

5

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Peter J Murray

6

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

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publication date

26 June 2009

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Europe PubMed Central

PMC publication ID

2 November 2017

Journal of Immunology

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Europe PubMed Central

PMC publication ID

2 November 2017

183

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

2

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

1301-1312

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Th2 cytokines in susceptibility to tuberculosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Tuberculosis: back on the immunologists' agenda

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Tuning of macrophage responses by Stat3-inducing cytokines: molecular mechanisms and consequences in infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Interleukin-10 suppression of myeloid cell activation--a continuing puzzle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Alternative activation of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Shaping gene expression in activated and resting primary macrophages by IL-10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Interleukin-10 and the interleukin-10 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Increased antimycobacterial immunity in interleukin-10-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Identification of nitric oxide synthase as a protective locus against tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Interleukin-10-deficient mice develop chronic enterocolitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Cytokine production at the site of disease in human tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Disseminated tuberculosis in interferon gamma gene-disrupted mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

Macrophage deactivation by interleukin 10

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

28 May 2018

General nature of the STAT3-activated anti-inflammatory response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Cutting edge: a new approach to modeling early lung immunity in murine tuberculosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Improved clearance of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735238

16 August 2018

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with Tuberculosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of IL-10 in promoting disease progression in leishmaniasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19561100

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.0803567

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 November 2017

ResearchGate publication ID

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