(Q42552199)

English

Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity

scientific article published on December 1996

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scholarly article

1 reference

Europe PubMed Central

2 November 2017

Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity (English)

1 reference

Europe PubMed Central

2 November 2017

author name string

Schock HB

1

1 reference

Europe PubMed Central

2 November 2017

Garsky VM

2

1 reference

Europe PubMed Central

2 November 2017

Kuo LC

3

1 reference

Europe PubMed Central

2 November 2017

language of work or name

0 references

publication date

1 December 1996

1 reference

Europe PubMed Central

2 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 November 2017

271

1 reference

Europe PubMed Central

2 November 2017

31957-31963

1 reference

Europe PubMed Central

2 November 2017

50

1 reference

Europe PubMed Central

2 November 2017

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Three-dimensional structure of a mutant HIV-1 protease displaying cross-resistance to all protease inhibitors in clinical trials.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Complete nucleotide sequence of the AIDS virus, HTLV-III

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Dissociation and association of the HIV-1 protease dimer subunits: equilibria and rates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing -hydrophobic*hydrophobic- or -aromatic*pro- cleavage sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Studies on the role of the S4 substrate binding site of HIV proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Kinetic and modeling studies of S3-S3' subsites of HIV proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Subsite preferences of retroviral proteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Human immunodeficiency virus type 1 protease inhibitors: evaluation of resistance engendered by amino acid substitutions in the enzyme's substrate binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Viral dynamics in human immunodeficiency virus type 1 infection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Clinical isolates of HIV-1 contain few pre-existing proteinase inhibitor resistance-conferring mutations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Resistance of HIV type 1 to proteinase inhibitor Ro 31-8959.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.50.31957

21 January 2018

Identifiers

10.1074/JBC.271.50.31957

1 reference

Europe PubMed Central

2 November 2017

1 reference

Europe PubMed Central

2 November 2017

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