Wikidata

(Q425649)

English

Low density lipoprotein receptor

mammalian protein found in Homo sapiens

  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor
  • LDL receptor
  • receptors, LDL
  • uniprot:P01130
  • LDLR
In more languages

Statements

molecular function
protein binding
determination method
IPI
13 references
retrieved
9 May 2017
stated in
Reelin is a ligand for lipoprotein receptors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01130
determination method
IPI
retrieved
8 April 2019
stated in
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR
GOA
curator
UniProt
UniProt protein ID
P01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2
GOA
curator
UniProt
UniProt protein ID
P01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus
GOA
curator
UniProt
UniProt protein ID
P01130
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for LDL receptor recognition by PCSK9
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
retrieved
8 April 2019
stated in
Reelin is a ligand for lipoprotein receptors
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IPI
low-density lipoprotein particle receptor activity
determination method
IC
IDA
IEA
IMP
TAS
7 references
retrieved
8 April 2019
stated in
Analysis of a recycling-impaired mutant of low density lipoprotein receptor in familial hypercholesterolemia
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
TAS
retrieved
8 April 2019
stated in
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
TAS
retrieved
8 April 2019
stated in
The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IEA
retrieved
8 April 2019
stated in
The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IDA
retrieved
8 April 2019
stated in
Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IDA
retrieved
8 April 2019
stated in
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IC
cell component
biological process
cholesterol homeostasis
determination method
IEA
IGI
IMP
TAS
5 references
retrieved
8 April 2019
stated in
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
TAS
retrieved
8 April 2019
stated in
The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IMP
retrieved
8 April 2019
stated in
Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IMP
retrieved
8 April 2019
stated in
Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01130
determination method
IEA
Gene Atlas image
PBB GE LDLR 202068 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D011973
subject named as
Receptors, LDL
0 references
Microsoft Academic ID
43554185
0 references
2909033353
0 references
PDB structure ID
 
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