(Q42609001)

English

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

scientific article published on October 1, 2003

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scholarly article

1 reference

Europe PubMed Central

3 November 2017

Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine (English)

1 reference

Europe PubMed Central

3 November 2017

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine (English)

1 reference

10.1124/MOL.64.4.823

https://api.crossref.org/works/10.1124/MOL.64.4.823

12 March 2024

1 reference

based on heuristic

inferred from title

mutational analysis

1 reference

based on heuristic

inferred from title

1 reference

10.1124/MOL.64.4.823

https://api.crossref.org/works/10.1124/MOL.64.4.823

12 March 2024

molecular medicine

1 reference

10.1124/MOL.64.4.823

https://api.crossref.org/works/10.1124/MOL.64.4.823

12 March 2024

author name string

Pari Malherbe

1

1 reference

Europe PubMed Central

3 November 2017

Nicole Kratochwil

2

1 reference

Europe PubMed Central

3 November 2017

Marie-Thérèse Zenner

3

1 reference

Europe PubMed Central

3 November 2017

Jenny Piussi

4

1 reference

Europe PubMed Central

3 November 2017

Catherine Diener

5

1 reference

Europe PubMed Central

3 November 2017

Claudia Kratzeisen

6

1 reference

Europe PubMed Central

3 November 2017

Christophe Fischer

7

1 reference

Europe PubMed Central

3 November 2017

Richard H. P. Porter

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14500738

12 March 2024

language of work or name

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14500738

12 March 2024

publication date

1 October 2003

1 reference

Europe PubMed Central

3 November 2017

full work available at URL

https://syndication.highwire.org/content/doi/10.1124/mol.64.4.823

1 reference

10.1124/MOL.64.4.823

https://api.crossref.org/works/10.1124/MOL.64.4.823

12 March 2024

Molecular Pharmacology

1 reference

Europe PubMed Central

3 November 2017

64

1 reference

Europe PubMed Central

3 November 2017

823-832

1 reference

Europe PubMed Central

3 November 2017

4

1 reference

Europe PubMed Central

3 November 2017

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

2

1 reference

10.1124/MOL.64.4.823

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12 March 2024

Molecular tinkering of G protein-coupled receptors: an evolutionary success

5

1 reference

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12 March 2024

Group I metabotropic glutamate receptors: implications for brain diseases

6

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Movement of retinal along the visual transduction path

7

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Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism.

8

1 reference

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

9

1 reference

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12 March 2024

Pharmacology and functions of metabotropic glutamate receptors

10

1 reference

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12 March 2024

Molecular determinants of metabotropic glutamate receptor signaling.

11

1 reference

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12 March 2024

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

12

1 reference

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12 March 2024

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

13

1 reference

10.1124/MOL.64.4.823

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12 March 2024

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

14

1 reference

10.1124/MOL.64.4.823

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12 March 2024

Charge distribution from a simple molecular orbital type calculation and non-bonding interaction terms in the force field MAB

15

1 reference

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12 March 2024

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

16

1 reference

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12 March 2024

Molecular Pharmacology

17

55

642

publication date

1992

1 reference

10.1124/MOL.64.4.823

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12 March 2024

Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia.

18

1 reference

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A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

19

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Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site

20

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21

1 reference

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Molecular Pharmacology

22

55

453

publication date

1999

1 reference

10.1124/MOL.64.4.823

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Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor

24

1 reference

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The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.

25

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The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

27

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

28

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A model for the functioning of family 3 GPCRs

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1 reference

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Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

30

1 reference

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Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

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Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells

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Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

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Rhodopsin: insights from recent structural studies.

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Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

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Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders

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Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

39

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Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

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Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

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Identifiers

10.1124/MOL.64.4.823

1 reference

Europe PubMed Central

3 November 2017

1 reference

Europe PubMed Central

3 November 2017

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