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English
RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.
scientific article published on March 1998
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scholarly article
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stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
(English)
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
main subject
cytoskeleton
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author
Richard Treisman
series ordinal
3
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Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Erik Sahai
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author name string
Alberts AS
series ordinal
2
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stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
language of work or name
English
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publication date
1 March 1998
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Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
published in
The EMBO Journal
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
17
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
1350-1361
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
5
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
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Prenylation of RhoB is required for its cell transforming function but not its ability to activate serum response element-dependent transcription
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The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization
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p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
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Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
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Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
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27 May 2018
The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue
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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways
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Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling
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RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
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27 May 2018
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
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27 May 2018
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.
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27 May 2018
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
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Ras effectors
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PubMed Central
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27 May 2018
The Dbl family of oncogenes
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27 May 2018
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
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27 May 2018
Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor
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Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
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Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
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27 May 2018
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain
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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
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Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning
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27 May 2018
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
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27 May 2018
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N
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27 May 2018
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho
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27 May 2018
A novel partner for the GTP-bound forms of rho and rac
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27 May 2018
A role for Rho in Ras transformation
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PubMed Central
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27 May 2018
ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.
1 reference
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PubMed Central
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27 May 2018
Tumorigenic activity of rho genes from Aplysia californica
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PubMed Central
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27 May 2018
Identification of multiple, novel, protein kinase C-related gene products
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Multiple Ras functions can contribute to mammalian cell transformation
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PubMed Central
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27 May 2018
Critical role of Rho in cell transformation by oncogenic Ras.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
retrieved
27 May 2018
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Mutational analysis of a ras catalytic domain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
retrieved
27 May 2018
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
retrieved
27 May 2018
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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27 May 2018
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170483
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16 August 2018
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9482732
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9482732
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9482732
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/EMBOJ/17.5.1350
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PMCID
1170483
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed ID
9482732
1 reference
stated in
Europe PubMed Central
PMCID
1170483
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9482732%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
ResearchGate publication ID
13748374
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