(Q42829672)

English

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

scientific article published on January 2001

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scholarly article

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6 November 2019

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret (English)

1 reference

Europe PubMed Central

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6 November 2019

Gabriella De Vita

3

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6 November 2019

Pietro Formisano

4

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6 November 2019

6

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6 November 2019

Rosa Marina Melillo

1

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6 November 2019

author name string

F Carlomagno

2

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6 November 2019

G Vecchio

5

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6 November 2019

M Billaud

7

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6 November 2019

M Santoro

8

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6 November 2019

language of work or name

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publication date

1 January 2001

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6 November 2019

1 reference

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6 November 2019

20

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6 November 2019

209-218

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6 November 2019

2

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6 November 2019

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204049

0 references

GDNF family neurotrophic factor signaling: four masters, one servant?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Grb2 binding to the different isoforms of Ret tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Identification of Shc docking site on Ret tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Glial cell line-derived neurotrophic factor differentially stimulates ret mutants associated with the multiple endocrine neoplasia type 2 syndromes and Hirschsprung's disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Shc and Enigma are both required for mitogenic signaling by Ret/ptc2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

RET mutations in human disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Signaling through scaffold, anchoring, and adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The role of phosphoinositide 3-kinase lipid products in cell function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The GDNF protein family: gene ablation studies reveal what they really do and how.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

How receptor tyrosine kinases activate Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

SH2/SH3 signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

21 January 2018

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

7 January 2021

based on heuristic

inferred from DOI database lookup

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

7 January 2021

based on heuristic

inferred from DOI database lookup

The surprisingly flexible PTB domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204049

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1204049

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313948%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

Dimensions Publication ID

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1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11313948%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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