(Q43068233)

13 November 2017

Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting (English)

1 reference

13 November 2017

1 reference

2

Hugues de Thé

0 references

Nasr Rihab

series ordinal

1

object named as

Rihab Nasr

1 reference

13 November 2017

11 May 2010

1 reference

International Journal of Hematology

13 November 2017

1 reference

13 November 2017

91

1 reference

13 November 2017

742-747

1 reference

13 November 2017

5

1 reference

https://scigraph.springernature.com/pub.10.1007/s12185-010-0582-0

13 November 2017

0 references

cites work

PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12185-010-0582-0

Favourable outcome in an APL patient with PLZF/RARalpha fusion gene: quantitative real-time RT-PCR confirms molecular response.

21 January 2018

1 reference

12 December 2020

Acute promyelocytic leukemia

1 reference

12 December 2020

Cancer stem cells: lessons from leukemia.

1 reference

12 December 2020

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

1 reference

12 December 2020

Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia

1 reference

12 December 2020

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

1 reference

12 December 2020

Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy

1 reference

12 December 2020

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

1 reference

12 December 2020

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

1 reference

12 December 2020

A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters

1 reference

12 December 2020

Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

1 reference

12 December 2020

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia.

1 reference

12 December 2020

Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC

1 reference

12 December 2020

Acute promyelocytic leukemia: from highly fatal to highly curable

1 reference

12 December 2020

Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

1 reference

12 December 2020

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

1 reference

12 December 2020

Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7

1 reference

12 December 2020

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

1 reference

12 December 2020

RXR is an essential component of the oncogenic PML/RARA complex in vivo

1 reference

12 December 2020

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein

1 reference

12 December 2020

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk

1 reference

12 December 2020

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells

1 reference

12 December 2020

Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

1 reference

12 December 2020

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

1 reference

12 December 2020

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

1 reference

12 December 2020

Curing APL: differentiation or destruction?

1 reference

12 December 2020

Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

1 reference

12 December 2020

Cyclin H binding to the RARalpha activation function (AF)-2 domain directs phosphorylation of the AF-1 domain by cyclin-dependent kinase 7.

1 reference

12 December 2020

PML targeting eradicates quiescent leukaemia-initiating cells

1 reference

12 December 2020

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

1 reference

12 December 2020

Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

1 reference

12 December 2020

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

1 reference

12 December 2020

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

1 reference

12 December 2020

Acute promyelocytic leukemia--weapons of mass differentiation.

1 reference

12 December 2020

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

1 reference

12 December 2020

Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity

1 reference

12 December 2020

Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia

1 reference

12 December 2020

Treatment of newly diagnosed and relapsed acute promyelocytic leukemia with intravenous liposomal all-trans retinoic acid

1 reference

12 December 2020

cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha

1 reference

12 December 2020

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1 reference

12 December 2020

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

1 reference

12 December 2020

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

12 December 2020

A sumoylation site in PML/RARA is essential for leukemic transformation.

1 reference

12 December 2020

Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia

1 reference

12 December 2020

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

1 reference

12 December 2020

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

1 reference

12 December 2020

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

1 reference

12 December 2020

A sustained increase in the endogenous level of cAMP reduces the retinoid concentration required for APL cell maturation to near physiological levels.

1 reference

12 December 2020

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion

1 reference

12 December 2020

Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

1 reference

12 December 2020

Modelling haematopoietic malignancies in the mouse and therapeutical implications

1 reference

12 December 2020

Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure

1 reference

12 December 2020

Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.

1 reference

12 December 2020

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

1 reference

12 December 2020

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1 reference

12 December 2020

PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

1 reference

12 December 2020

Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia

1 reference

12 December 2020

Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.

1 reference

12 December 2020

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

1 reference

12 December 2020

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

1 reference

12 December 2020

All trans retinoic acid in acute promyelocytic leukemia

1 reference

12 December 2020

Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells

1 reference

12 December 2020

Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes.

1 reference

12 December 2020

Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

1 reference

12 December 2020

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

1 reference

12 December 2020

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

1 reference

12 December 2020

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

1 reference

12 December 2020

10.1007/S12185-010-0582-0

Identifiers

DOI

1 reference

13 November 2017

1 reference

PubMed ID

20455087