(Q43729274)

26 November 2017

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis (English)

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26 November 2017

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26 November 2017

Bardeesy N

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26 November 2017

Lee KH

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26 November 2017

Carrasco D

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26 November 2017

Castrillon DH

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26 November 2017

Aguirre AJ

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26 November 2017

Wu EA

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26 November 2017

Horner JW

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26 November 2017

DePinho RA

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26 November 2017

language of work or name

English

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publication date

1 September 2001

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26 November 2017

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413

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86-91

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26 November 2017

6851

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https://scigraph.springernature.com/pub.10.1038/35092592

26 November 2017

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cites work

The INK4A/ARF locus and its two gene products

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

21 January 2018

1 reference

Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

21 January 2018

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

21 January 2018

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 January 2018

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

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Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

21 January 2018

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Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

21 January 2018

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Frequent aberrant methylation of p16INK4a in primary rat lung tumors

21 January 2018

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Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis

21 January 2018

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Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

21 January 2018

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D-type cyclin-dependent kinase activity in mammalian cells

21 January 2018

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p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/35092592

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Dimensions Publication ID

26 November 2017

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