(Q43730373)

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HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus

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scholarly article

1 reference

Europe PubMed Central

26 November 2017

HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus (English)

1 reference

Europe PubMed Central

26 November 2017

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author name string

Riddle TM

1

1 reference

Europe PubMed Central

26 November 2017

Kuhel DG

2

1 reference

Europe PubMed Central

26 November 2017

Woollett LA

3

1 reference

Europe PubMed Central

26 November 2017

Fichtenbaum CJ

4

1 reference

Europe PubMed Central

26 November 2017

Hui DY

5

1 reference

Europe PubMed Central

26 November 2017

language of work or name

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publication date

23 August 2001

1 reference

Europe PubMed Central

26 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

26 November 2017

276

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Europe PubMed Central

26 November 2017

37514-37519

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Europe PubMed Central

26 November 2017

40

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Europe PubMed Central

26 November 2017

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

HIV-protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Development of cervical fat pads following therapy with human immunodeficiency virus type 1 protease inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Hyperlipidemia associated with protease inhibitor therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Ritonavir increases the level of active ADD-1/SREBP-1 protein during adipogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Transcriptional regulation of gene expression during adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Decrease of HIV-1 RNA levels in lymphoid tissue and peripheral blood during treatment with ritonavir, lamivudine and zidovudine. Ritonavir/3TC/ZDV Study Group

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Changes in AIDS incidence for men who have sex with men, United States 1990-1995.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Salvage therapy with regimens containing ritonavir and saquinavir in extensively pretreated HIV-infected patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M104557200

21 January 2018

Identifiers

10.1074/JBC.M104557200

1 reference

Europe PubMed Central

26 November 2017

1 reference

Europe PubMed Central

26 November 2017

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