(Q43800246)

English

ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth

scientific article published in November 2001

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scholarly article

1 reference

Europe PubMed Central

26 November 2017

ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth (English)

1 reference

Europe PubMed Central

26 November 2017

1 reference

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author name string

U Hermanto

1

1 reference

Europe PubMed Central

26 November 2017

C S Zong

2

1 reference

Europe PubMed Central

26 November 2017

L H Wang

3

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Europe PubMed Central

26 November 2017

language of work or name

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publication date

1 November 2001

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Europe PubMed Central

26 November 2017

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Europe PubMed Central

26 November 2017

20

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Europe PubMed Central

26 November 2017

7551-7562

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Europe PubMed Central

26 November 2017

51

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Europe PubMed Central

26 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204964

0 references

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Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Regulation of cell death protease caspase-9 by phosphorylation

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erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

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Ribosomal S6 kinase signaling and the control of translation

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Phosphoinositide kinases

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

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Overexpression of c-erbB2 is an independent marker of resistance to endocrine therapy in advanced breast cancer

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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Mitogen-activated protein kinase pathways

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HER2/neu antisense targeting of human breast carcinoma

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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CDK inhibitors: positive and negative regulators of G1-phase progression

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

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Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

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Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

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HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

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Lipid-Regulated Kinases: Some Common Themes at Last

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G1 phase arrest by the phosphatidylinositol 3-kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal melanoma cells

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Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms

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7 January 2021

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Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential.

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10.1038/SJ.ONC.1204964

1 reference

Europe PubMed Central

26 November 2017

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1 reference

Europe PubMed Central

26 November 2017

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