(Q43862472)

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Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA.

scientific article published in January 2002

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scholarly article

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Europe PubMed Central

27 November 2017

Human urinary bladder epithelial cells lacking wild-type p53 function are deficient in the repair of 4-aminobiphenyl-DNA adducts in genomic DNA. (English)

1 reference

Europe PubMed Central

27 November 2017

author name string

Santhanam Swaminathan

1

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Europe PubMed Central

27 November 2017

Jennifer L Torino

2

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Europe PubMed Central

27 November 2017

Melissa S Burger

3

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Europe PubMed Central

27 November 2017

language of work or name

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publication date

1 January 2002

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Europe PubMed Central

27 November 2017

Mutation Research

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Europe PubMed Central

27 November 2017

499

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Europe PubMed Central

27 November 2017

103-117

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Europe PubMed Central

27 November 2017

1

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Europe PubMed Central

27 November 2017

Epidemiology of cancer from exposure to arylamines

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Urothelial cancer and some industry-related chemicals: an evaluation of the epidemiologic literature

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Bladder cancer incidence in arylamine workers

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DNA adducts in urothelial cells: relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke

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N-Glucuronidation of N-hydroxy aromatic amines: A mechanism for their transport and bladder-specific carcinogenicity

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Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers

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Detection of deoxyadenosine-4-aminobiphenyl adduct in DNA of human uroepithelial cells treated with N-hydroxy-4-aminobiphenyl following nuclease P1 enrichment and 32P-postlabeling analysis

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Role of TP53 in repair of N-(deoxyguanosin-8-yl)-4-aminobiphenyl adducts in human transitional cell carcinoma of the urinary bladder

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DNA damage in human transitional cell carcinoma cells after exposure to the proximate metabolite of the bladder carcinogen 4-aminobiphenyl

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Oxidative damage to DNA in mammalian chromatin

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Oxyradicals and DNA damage

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Twenty years of p53 research: structural and functional aspects of the p53 protein

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p53: puzzle and paradigm

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Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

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Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

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Wildtype p53 is required for heat shock and ultraviolet light enhanced repair of a UV-damaged reporter gene

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p53-degradation by HPV-16 E6 preferentially affects the removal of cyclobutane pyrimidine dimers from non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation

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Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair

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p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

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Faulty DNA polymerase delta/epsilon-mediated excision repair in response to gamma radiation or ultraviolet light in p53-deficient fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome

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Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

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Regulation of p53 in response to DNA damage

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WAF1, a potential mediator of p53 tumor suppression

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Methotrexate resistance in human uroepithelial cells with p53 alterations

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32P-labeling test for DNA damage

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32P-postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans

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7 January 2021

A new synthetic route to nucleotide adducts derived from N-acetylated and unacetylated 4-aminobiphenyl.

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Acetyl transferase-mediated metabolic activation of N-hydroxy-4-aminobiphenyl by human uroepithelial cells

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Mutagenic activation of 4-aminobiphenyl and its N-hydroxy derivatives by microsomes from cultured human uroepithelial cells.

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7 January 2021

32P-postlabeling analysis of adducts generated by peroxidase-mediated binding of N-hydroxy-4-acetylaminobiphenyl to DNA.

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Decreased DNA repair efficiency by loss or disruption of p53 function preferentially affects removal of cyclobutane pyrimidine dimers from non-transcribed strand and slow repair sites in transcribed strand.

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

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p53 mutations in human cancers

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Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

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Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis

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Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

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p53 modulation of TFIIH-associated nucleotide excision repair activity

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7 January 2021

Identifiers

10.1016/S0027-5107(01)00271-8

1 reference

Europe PubMed Central

27 November 2017

1 reference

Europe PubMed Central

27 November 2017

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