(Q43874033)

27 November 2017

title

A conserved tryptophan 457 modulates the kinetics and extent of N-hydroxy-L-arginine oxidation by inducible nitric-oxide synthase (English)

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27 November 2017

2

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27 November 2017

Zhi-Qiang Wang

1

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27 November 2017

Dennis J Stuehr

series ordinal

3

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27 November 2017

language of work or name

English

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publication date

31 January 2002

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Journal of Biological Chemistry

27 November 2017

published in

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27 November 2017

volume

277

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27 November 2017

issue

15

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27 November 2017

page(s)

12830-12837

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Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

27 November 2017

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Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

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Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.

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RNA diversity has profound effects on the translation of neuronal nitric oxide synthase

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Differences in three kinetic parameters underpin the unique catalytic profiles of nitric-oxide synthases I, II, and III.

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Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation

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Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors

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Chimeras of nitric-oxide synthase types I and III establish fundamental correlates between heme reduction, heme-NO complex formation, and catalytic activity

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Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase

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Low-temperature stabilization and spectroscopic characterization of the dioxygen complex of the ferrous neuronal nitric oxide synthase oxygenase domain

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Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin.

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CNS-Specific Ribozyme Expression

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Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism

21 January 2018

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Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.

21 January 2018

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A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin

21 January 2018

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Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457

21 January 2018

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Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy.

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Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.

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21 January 2018

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Regulation of inducible nitric oxide synthase by self-generated NO.

21 January 2018

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Probing electron transfer in flavocytochrome P-450 BM3 and its component domains

21 January 2018

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Relationship between the rate of reductase-cytochrome P450 complex formation and the rate of first electron transfer

21 January 2018

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21 January 2018

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Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine

21 January 2018

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Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

21 January 2018

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Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases

21 January 2018

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Catalysis by nitric oxide synthase

21 January 2018

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The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability

21 January 2018

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The Ferrous Dioxygen Complex of the Oxygenase Domain of Neuronal Nitric-oxide Synthase

21 January 2018

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Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase

21 January 2018

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Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism

21 January 2018

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Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

21 January 2018

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Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline

21 January 2018

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Low-Temperature Optical Absorption Spectra Suggest a Redox Role for Tetrahydrobiopterin in Both Steps of Nitric Oxide Synthase Catalysis†

21 January 2018

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The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase

21 January 2018

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Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions

21 January 2018

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Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase

21 January 2018

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Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline

21 January 2018

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Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase

21 January 2018

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Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M111967200

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27 November 2017

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