(Q44111868)

29 November 2017

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title

A network view of disease and compound screening (English)

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29 November 2017

2

Stephen H Friend

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29 November 2017

1

Eric E Schadt

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29 November 2017

David A Shaywitz

3

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29 November 2017

publication date

1 April 2009

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Nature Reviews Drug Discovery

29 November 2017

published in

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29 November 2017

volume

8

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29 November 2017

issue

4

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29 November 2017

page(s)

286-295

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Can the pharmaceutical industry reduce attrition rates?

29 November 2017

cites work

1 reference

Network biology: understanding the cell's functional organization

31 March 2020

1 reference

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

31 March 2020

1 reference

Variations in DNA elucidate molecular networks that cause disease

31 March 2020

1 reference

Genetics of gene expression and its effect on disease

31 March 2020

1 reference

Genomic analysis of metabolic pathway gene expression in mice

31 March 2020

1 reference

Discovering regulatory and signalling circuits in molecular interaction networks

31 March 2020

1 reference

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

31 March 2020

1 reference

An integrative genomics approach to infer causal associations between gene expression and disease

31 March 2020

1 reference

Genetics of gene expression surveyed in maize, mouse and man

31 March 2020

1 reference

Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

1 reference

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity

31 March 2020

1 reference

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

31 March 2020

1 reference

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits

31 March 2020

1 reference

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

1 reference

Genome-wide association studies provide new insights into type 2 diabetes aetiology

31 March 2020

1 reference

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

31 March 2020

1 reference

Genomewide association analysis of coronary artery disease

31 March 2020

1 reference

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

31 March 2020

1 reference

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

31 March 2020

1 reference

An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

1 reference

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

31 March 2020

1 reference

A gene-expression signature as a predictor of survival in breast cancer

31 March 2020

1 reference

Genetic mapping in human disease

31 March 2020

1 reference

HTRA1 promoter polymorphism in wet age-related macular degeneration

31 March 2020

1 reference

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

31 March 2020

1 reference

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

31 March 2020

1 reference

A whole-genome association study of major determinants for host control of HIV-1

31 March 2020

1 reference

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

31 March 2020

1 reference

Genetic inheritance of gene expression in human cell lines

31 March 2020

1 reference

Genetic analysis of genome-wide variation in human gene expression

31 March 2020

1 reference

A genome-wide association study of global gene expression

31 March 2020

1 reference

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

31 March 2020

1 reference

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

31 March 2020

1 reference

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

31 March 2020

1 reference

Mapping the genetic architecture of gene expression in human liver

31 March 2020

1 reference

Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations

31 March 2020

1 reference

Epigenetic transgenerational actions of endocrine disruptors and male fertility

31 March 2020

1 reference

Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease

31 March 2020

1 reference

Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination

31 March 2020

1 reference

An integrative genomics approach to the reconstruction of gene networks in segregating populations.

31 March 2020

1 reference

A systems biology approach to drug discovery

31 March 2020

1 reference

Integrating genetic and network analysis to characterize genes related to mouse weight

31 March 2020

1 reference

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

31 March 2020

1 reference

A new grammar for drug discovery

31 March 2020

1 reference

The molecular biography of the cell

31 March 2020

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The continuing dilemma in clinical investigation and the future of American health care: a system-wide problem requiring collaborative solutions

31 March 2020

1 reference

Attrition and Translation

31 March 2020

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The clinical investigator: bewitched, bothered, and bewildered--but still beloved

31 March 2020

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Patient-oriented research: principles and new approaches to training

31 March 2020

1 reference

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists

31 March 2020

1 reference

Functional discovery via a compendium of expression profiles

31 March 2020

1 reference

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

31 March 2020

1 reference

Systems biology and combination therapy in the quest for clinical efficacy.

31 March 2020

1 reference

Lipid traffic: floppy drives and a superhighway.

31 March 2020

1 reference

Network pharmacology: the next paradigm in drug discovery

31 March 2020

1 reference

The Connectivity Map: a new tool for biomedical research

31 March 2020

1 reference

Towards a proteome-scale map of the human protein–protein interaction network

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/19337271

31 March 2020

1 reference

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The essential role of integrative biomedical sciences in protecting and contributing to the health and well-being of our nation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19337271

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD2826

1 reference

Dimensions Publication ID

29 November 2017

1000699125

0 references

1 reference