(Q44116130)

English

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

scientific article published on 26 August 2002

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scholarly article

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12 November 2019

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12198119%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

apoptotic process

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based on heuristic

inferred from title

Consuelo Gajate

1

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12 November 2019

Faustino Mollinedo

3

object named as

Faustino Mollinedo

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12 November 2019

author name string

Feiyun An

2

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12 November 2019

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26 August 2002

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12 November 2019

Journal of Biological Chemistry

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12 November 2019

277

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12 November 2019

41580-41589

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12 November 2019

44

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12 November 2019

In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Early and selective induction of apoptosis in human leukemic cells by the alkyl-lysophospholipid ET-18-OCH3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Aspirin induces apoptosis through mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Caspases: killer proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Intracellular alkalinization suppresses lovastatin-induced apoptosis in HL-60 cells through the inactivation of a pH-dependent endonuclease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Cyclin G2 is up-regulated during growth inhibition and B cell antigen receptor-mediated cell cycle arrest.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Identification of a functional domain in a GADD45-mediated G2/M checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

The central executioners of apoptosis: caspases or mitochondria?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204644200

21 January 2018

Identifiers

10.1074/JBC.M204644200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12198119%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12198119%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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