(Q44133854)

30 November 2017

title

The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence (English)

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30 November 2017

1

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30 November 2017

M Claire Bartlett

2

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30 November 2017

David M Clarke

series ordinal

3

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30 November 2017

language of work or name

English

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publication date

10 September 2002

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Journal of Biological Chemistry

30 November 2017

published in

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30 November 2017

volume

277

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30 November 2017

issue

44

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30 November 2017

page(s)

41303-41306

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ABC Transporters: From Microorganisms to Man

30 November 2017

cites work

1 reference

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 January 2018

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

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ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

21 January 2018

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Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

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Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

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P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

21 January 2018

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

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The anatomy and taxonomy of protein structure

21 January 2018

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P-glycoprotein. Associations between domains and between domains and molecular chaperones

21 January 2018

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Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

21 January 2018

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Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

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Crystal structure of the ATP-binding subunit of an ABC transporter

21 January 2018

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Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis

21 January 2018

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

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Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

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Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

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Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.C200484200

1 reference

30 November 2017

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