(Q44319782)

1 December 2017

Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling (English)

1 reference

1 December 2017

1 reference

1 reference

Donglei Zhang

1

1 reference

PubMed ID

12592384

1 December 2017

Pnina Brodt

series ordinal

2

1 reference

PubMed ID

12592384

1 December 2017

language of work or name

English

0 references

publication date

1 February 2003

1 reference

1 December 2017

1 reference

1 December 2017

22

1 reference

1 December 2017

974-982

1 reference

1 December 2017

7

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206197

1 December 2017

0 references

cites work

Controlling IGF-receptor function: a possible strategy for tumor therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Differences in the repertoires of basement membrane degrading enzymes in two carcinoma sublines with distinct patterns of site-selective metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Matrix metalloproteinases in tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy in cultured neonatal rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

The Akt kinase signals directly to endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Stem cells. PTEN--coupling tumor suppression to stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

ERK signalling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

PTEN expression causes feedback upregulation of insulin receptor substrate 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Regulation of survival and death of mesangial cells by extracellular matrix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Hepatocyte growth factor enhances MMP activity in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and phosphatidylinositol 3-kinase dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Role of MT-MMPs and MMP-2 in pancreatic cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Increased gelatinase-A and gelatinase-B activities in malignant vs. benign breast tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Insulin-like growth factors and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Membrane-type metalloproteinases in tumor invasion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Insulin-like growth factor signaling pathways in rat hepatic stellate cells: importance for deoxyribonucleic acid synthesis and hepatocyte growth factor production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Integrative mitogenic role of protein kinase B/Akt in beta-cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Matrix metalloproteinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206197

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206197

1 reference

1 December 2017

1 reference

PubMed ID

12592384