(Q44420467)

2 December 2017

title

Alpha-Synuclein is degraded by both autophagy and the proteasome (English)

1 reference

2 December 2017

α-Synuclein Is Degraded by Both Autophagy and the Proteasome (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

28 December 2023

1 reference

1 reference

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

28 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

28 December 2023

author name string

Brinda Ravikumar

2

1 reference

2 December 2017

Jane Atkins

3

1 reference

2 December 2017

Julie L. Webb

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719433

28 December 2023

Jeremy N. Skepper

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719433

28 December 2023

David C. Rubinsztein

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719433

28 December 2023

language of work or name

English

0 references

publication date

28 April 2003

1 reference

full work available at URL

2 December 2017

http://www.jbc.org/article/S0021925820869646/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719433

https://api.elsevier.com/content/article/PII:S0021925820869646?httpAccept=text/xml

28 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

https://api.elsevier.com/content/article/PII:S0021925820869646?httpAccept=text/plain

28 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

https://syndication.highwire.org/content/doi/10.1074/jbc.M300227200

28 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Journal of Biological Chemistry

28 December 2023

published in

1 reference

2 December 2017

volume

278

1 reference

2 December 2017

issue

27

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2 December 2017

page(s)

25009-25013

1 reference

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

2 December 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1073/PNAS.73.7.2424

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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4 November 2023

https://opencitations.net/index/coci/api/v1/citations/10.1038/33416

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

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Alpha-synuclein in Lewy bodies

28 December 2023

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Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease

28 December 2023

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https://api.crossref.org/works/10.1074/JBC.M300227200

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

28 December 2023

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https://api.crossref.org/works/10.1074/JBC.M300227200

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

28 December 2023

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A Drosophila model of Parkinson's disease

28 December 2023

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

28 December 2023

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

28 December 2023

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Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus

28 December 2023

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

28 December 2023

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The ubiquitin pathway in Parkinson's disease

28 December 2023

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The ubiquitin-proteasome pathway: on protein death and cell life

28 December 2023

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https://api.crossref.org/works/10.1074/JBC.M300227200

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

28 December 2023

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https://api.crossref.org/works/10.1074/JBC.M300227200

Degradation of alpha-synuclein by proteasome

28 December 2023

15

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https://api.crossref.org/works/10.1074/JBC.M300227200

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

28 December 2023

16

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

28 December 2023

17

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

28 December 2023

18

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

28 December 2023

19

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Vacuolar import of proteins and organelles from the cytoplasm

28 December 2023

20

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

28 December 2023

21

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

28 December 2023

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Immunocytochemical strategies for electron microscopy: choice or compromise

28 December 2023

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A molecular investigation of true dominance in Huntington's disease

28 December 2023

26

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https://api.crossref.org/works/10.1074/JBC.M300227200

Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/beta-lactone is not a specific inhibitor of the proteasome

28 December 2023

27

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

28 December 2023

29

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

28 December 2023

30

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

28 December 2023

31

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

28 December 2023

32

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

28 December 2023

33

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

28 December 2023

34

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

28 December 2023

35

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

28 December 2023

36

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator

28 December 2023

37

1 reference

https://api.crossref.org/works/10.1074/JBC.M300227200

28 December 2023

Identifiers

1 reference

2 December 2017

1 reference