(Q44563558)

4 December 2017

Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species (English)

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4 December 2017

J Matthew Hutzler

1

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4 December 2017

Frank J Powers

series ordinal

2

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4 December 2017

Michael A Wynalda

series ordinal

3

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4 December 2017

Larry C Wienkers

series ordinal

4

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4 December 2017

language of work or name

English

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publication date

1 September 2003

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Archives of Biochemistry and Biophysics

4 December 2017

11

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based on heuristic

inferred from page(s)

published in

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4 December 2017

417

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4 December 2017

165-175

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4 December 2017

2

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The human hepatic cytochromes P450 involved in drug metabolism

4 December 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Polymorphic hydroxylation of Debrisoquine in man.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Human cytochrome P450s: selectivity and measurement in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Influence of ionic strength on the P450 monooxygenase reaction and role of cytochrome b5 in the process

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Electronic models for cytochrome P450 oxidations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Role of Thr-252 in cytochrome P450cam: a study with unnatural amino acid mutagenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Oxygen activation by cytochrome P-450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Ipso-substitution by cytochrome P450 with conversion of p-hydroxybenzene derivatives to hydroquinone: evidence for hydroperoxo-iron as the active oxygen species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Evidence for two different active oxygen species in cytochrome P450 BM3 mediated sulfoxidation and N-dealkylation reactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

On the mechanism of amine oxidations by P450.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Two-state reactivity mechanisms of hydroxylation and epoxidation by cytochrome P-450 revealed by theory.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Cytochrome P450 4A and 2E1 expression in human kidney microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Human cytochromes mediating N-demethylation of fluoxetine in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0003-9861%2803%2900350-3

10.1016/S0003-9861(03)00350-3

7 January 2021

Identifiers

DOI

1 reference

4 December 2017

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