(Q4459741)

English

Toll like receptor 1

mammalian protein found in Homo sapiens

TIL
toll-like receptor 1
TLR1
toll/interleukin-1 receptor-like protein

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

toll-like receptor

0 references

Toll-like receptor 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15399

Toll/interleukin-1 receptor homology (TIR) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15399

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15399

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

Toll-like receptor 2 binding

determination method

1 reference

17 October 2017

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

protein binding

determination method

3 references

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

lipopeptide binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

transmembrane signaling receptor activity

determination method

3 references

17 October 2017

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

Toll-like receptor 2 binding

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

identical protein binding

determination method

1 reference

8 April 2019

Isolated Toll-like receptor transmembrane domains are capable of oligomerization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

phagocytic vesicle membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

plasma membrane

determination method

Toll-like receptor 1-Toll-like receptor 2 protein complex

determination method

1 reference

17 October 2017

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

integral component of plasma membrane

determination method

1 reference

17 October 2017

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

biological process

defense response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

toll-like receptor TLR1:TLR2 signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

cellular response to triacyl bacterial lipopeptide

determination method

toll-like receptor 1 signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

signal transduction

determination method

3 references

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

A family of human receptors structurally related to Drosophila Toll

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

innate immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

defense response to bacterium

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15399&geneProductId=UniProtKB:Q15399

determination method

cell activation

determination method

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

immune response

determination method

1 reference

8 April 2019

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

inflammatory response

determination method

positive regulation of toll-like receptor 2 signaling pathway

determination method

1 reference

8 April 2019

TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

cellular response to triacyl bacterial lipopeptide

determination method

3 references

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15399

determination method

Gene Atlas image

PBB GE TLR1 210176 at fs.png
732 × 530; 10 KB

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000421259

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421259

ENSP00000354932

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354932

ENSP00000421856

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421856

ENSP00000423017

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423017

ENSP00000423725

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423725

ENSP00000424894

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424894

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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