(Q44633634)

4 December 2017

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title

Hypoxia, HIF1 and glucose metabolism in the solid tumour (English)

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4 December 2017

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Nicholas C Denko

1

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PubMed ID

19143055

4 December 2017

language of work or name

English

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publication date

1 September 2008

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4 December 2017

Nature Reviews Cancer

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4 December 2017

8

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4 December 2017

705-713

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4 December 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc2468

4 December 2017

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cites work

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

1 reference

Should single or distributed parameters be used to explain the steepness of tumour control probability curves?

31 March 2020

1 reference

Investigating hypoxic tumor physiology through gene expression patterns

31 March 2020

1 reference

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

31 March 2020

1 reference

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

31 March 2020

1 reference

Hypoxia-inducible factor-1 and oncogenic signalling

31 March 2020

1 reference

Mitochondrial tumour suppressors: a genetic and biochemical update

31 March 2020

1 reference

Hypoxia signalling controls metabolic demand

31 March 2020

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

31 March 2020

1 reference

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

31 March 2020

1 reference

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

31 March 2020

1 reference

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha

31 March 2020

1 reference

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

31 March 2020

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

1 reference

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

31 March 2020

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

31 March 2020

1 reference

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

31 March 2020

1 reference

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

31 March 2020

1 reference

Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways

31 March 2020

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

1 reference

Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

31 March 2020

1 reference

Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway

31 March 2020

1 reference

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

31 March 2020

1 reference

Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

31 March 2020

1 reference

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

31 March 2020

1 reference

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

31 March 2020

1 reference

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

31 March 2020

1 reference

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

31 March 2020

1 reference

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

31 March 2020

1 reference

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

31 March 2020

1 reference

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

31 March 2020

1 reference

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

31 March 2020

1 reference

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

31 March 2020

1 reference

In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.

31 March 2020

1 reference

Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts

31 March 2020

1 reference

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

31 March 2020

1 reference

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

31 March 2020

1 reference

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

31 March 2020

1 reference

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

31 March 2020

1 reference

Glucose transporters: structure, function and consequences of deficiency

31 March 2020

1 reference

Neoangiogenesis and expression of hypoxia-inducible factor 1alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas

31 March 2020

1 reference

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

31 March 2020

1 reference

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

31 March 2020

1 reference

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

31 March 2020

1 reference

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

31 March 2020

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

Hypoxic Regulation of Lactate Dehydrogenase A

31 March 2020

1 reference

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

31 March 2020

1 reference

Deviant energetic metabolism of glycolytic cancer cells

31 March 2020

1 reference

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases

31 March 2020

1 reference

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

31 March 2020

1 reference

Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

31 March 2020

1 reference

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

31 March 2020

1 reference

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

31 March 2020

1 reference

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

31 March 2020

1 reference

Isoforms of yeast cytochrome c oxidase subunit V affect the binuclear reaction center and alter the kinetics of interaction with the isoforms of yeast cytochrome c.

31 March 2020

1 reference

Effects of a transition from normoxia to anoxia on yeast cytochrome c oxidase and the mitochondrial respiratory chain: implications for hypoxic gene induction

31 March 2020

1 reference

Why do cancers have high aerobic glycolysis?

31 March 2020

1 reference

Free radicals in the physiological control of cell function

31 March 2020

1 reference

Increased expression of uncoupling protein 2 in HepG2 cells attenuates oxidative damage and apoptosis

31 March 2020

1 reference

Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury

31 March 2020

1 reference

Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

31 March 2020

1 reference

Reactive species mediated injury of human lung epithelial cells after hypoxia-reoxygenation

31 March 2020

1 reference

Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia

31 March 2020

1 reference

Cellular oxygen sensing by mitochondria: old questions, new insight

31 March 2020

1 reference

Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment

31 March 2020

1 reference

c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1.

31 March 2020

1 reference

Brick by brick: metabolism and tumor cell growth

31 March 2020

1 reference

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

31 March 2020

1 reference

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

31 March 2020

1 reference

ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

1 reference

Regulation of skeletal alpha-actin promoter in young chickens during hypertrophy caused by stretch overload

31 March 2020

1 reference

The histological structure of some human lung cancers and the possible implications for radiotherapy

31 March 2020

1 reference

Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors

31 March 2020

1 reference

Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation

31 March 2020

1 reference

Oxygen consumption rates and oxygen concentration in molt-4 cells and their mtDNA depleted (rho0) mutants

31 March 2020

1 reference

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

31 March 2020

1 reference

The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

31 March 2020

1 reference

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

31 March 2020

1 reference

Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines

31 March 2020

1 reference

Non-respiratory oxygen consumption pathways in anaerobically-grown Saccharomyces cerevisiae: evidence and partial characterization

31 March 2020

1 reference

Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism

31 March 2020

1 reference

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.

31 March 2020

1 reference

Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

31 March 2020

1 reference

Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression.

31 March 2020

1 reference

Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

31 March 2020

1 reference

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

31 March 2020

1 reference

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

31 March 2020

1 reference

Reversibility of inhibition of DNA double strand break repair by 2-deoxy-D-glucose in Ehrlich ascites tumour cells.

31 March 2020

1 reference

Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells

31 March 2020

1 reference

HIF-1-regulated glucose metabolism: a key to apoptosis resistance?

31 March 2020

1 reference

2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.

31 March 2020

1 reference

Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

31 March 2020

1 reference

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

HIF-1 as a target for drug development

31 March 2020

1 reference

Targeting hypoxia cell signaling for cancer therapy

31 March 2020

1 reference

Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy

31 March 2020

1 reference

Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine

31 March 2020

1 reference

Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation O

31 March 2020

1 reference

p53 regulates mitochondrial respiration

31 March 2020

1 reference

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

31 March 2020

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

31 March 2020

1 reference

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo.

31 March 2020

1 reference

The oxygen dependence of cellular energy metabolism

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC2468

1 reference

4 December 2017

1 reference

PubMed ID

19143055