(Q44728792)

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Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

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Europe PubMed Central

PubMed publication ID

5 December 2017

Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease (English)

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Europe PubMed Central

PubMed publication ID

5 December 2017

Alzheimer's disease

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5 December 2017

6

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Europe PubMed Central

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5 December 2017

Rudolph E. Tanzi

5

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Rudolph E Tanzi

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Europe PubMed Central

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5 December 2017

Sandra M Payton

4

object named as

Sandra M Payton

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5 December 2017

1

object named as

Seiichi Nagano

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5 December 2017

author name string

Xudong Huang

2

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5 December 2017

language of work or name

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publication date

14 January 2004

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5 December 2017

Journal of Biological Chemistry

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5 December 2017

279

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5 December 2017

15

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5 December 2017

14673-14678

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Europe PubMed Central

PubMed publication ID

5 December 2017

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

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Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

1 reference

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

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Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

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Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

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In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation

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Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313003200

21 January 2018

Cyclooxygenases: structural, cellular, and molecular biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313003200

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Clinical trial of indomethacin in Alzheimer's disease.

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Nonsteroidal anti-inflammatory drug use and Alzheimer's disease: a case-control study in Rochester, Minnesota, 1980 through 1984.

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Induction of cyclo-oxygenase 2 in brains of patients with Down's syndrome and dementia of Alzheimer type: specific localization in affected neurones and axons.

1 reference

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21 January 2018

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1 reference

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Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

1 reference

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Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313003200

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Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology

1 reference

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Oxygen toxicity, oxygen radicals, transition metals and disease

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Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313003200

21 January 2018

Oxidative and hydrolytic properties of beta-amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313003200

21 January 2018

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

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21 January 2018

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease

1 reference

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21 January 2018

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

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21 January 2018

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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Tyrosyl radicals in prostaglandin H synthase-1 and -2.

1 reference

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Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins

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21 January 2018

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

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21 January 2018

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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21 January 2018

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

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21 January 2018

Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins

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https://api.crossref.org/works/10.1074%2FJBC.M313003200

21 January 2018

Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation

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21 January 2018

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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21 January 2018

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

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Neuropathological stageing of Alzheimer-related changes

1 reference

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

1 reference

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21 January 2018

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M313003200

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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