(Q44918417)

7 December 2017

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title

Gamma-secretase: proteasome of the membrane? (English)

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7 December 2017

1

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7 December 2017

Ma Xenia G Ilagan

2

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7 December 2017

1 June 2004

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Nature Reviews Molecular Cell Biology

7 December 2017

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7 December 2017

5

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7 December 2017

499-504

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7 December 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrm1406

7 December 2017

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31 March 2020

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

31 March 2020

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31 March 2020

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

31 March 2020

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

31 March 2020

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

31 March 2020

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Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

31 March 2020

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Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

31 March 2020

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

31 March 2020

1 reference

Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events

31 March 2020

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Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

31 March 2020

1 reference

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

31 March 2020

1 reference

Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor

31 March 2020

1 reference

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1406

1 reference

PubMed ID

15173829

Dimensions Publication ID

7 December 2017

0 references

1 reference

PubMed ID

15173829