(Q45078363)

9 December 2017

Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation (English)

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9 December 2017

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Bradley T Hyman

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9 December 2017

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Matthew P Frosch

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9 December 2017

Alberto Lleó

1

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9 December 2017

Oksana Berezovska

2

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9 December 2017

Lauren Herl

3

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9 December 2017

Susan Raju

4

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9 December 2017

Amy Deng

5

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9 December 2017

Brian J Bacskai

6

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9 December 2017

Michael Irizarry

8

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9 December 2017

language of work or name

English

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publication date

26 September 2004

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9 December 2017

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9 December 2017

10

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9 December 2017

1065-1066

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9 December 2017

10

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https://scigraph.springernature.com/pub.10.1038/nm1112

9 December 2017

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cites work

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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7 January 2021

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

7 January 2021

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

7 January 2021

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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7 January 2021

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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7 January 2021

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

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7 January 2021

Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.

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7 January 2021

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

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7 January 2021

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

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7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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7 January 2021

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

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7 January 2021

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

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7 January 2021

Identifiers

DOI

10.1038/NM1112

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Dimensions Publication ID

9 December 2017

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