(Q45110672)

9 December 2017

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase (English)

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3C-like proteinase [SARS-Cov]

9 December 2017

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author

Lindsay D. Eltis

6

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9 December 2017

Carly Huitema

3

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author name string

Jan E Blanchard

1

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9 December 2017

Nadine H Elowe

2

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9 December 2017

Pascal D Fortin

4

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9 December 2017

Jonathan D Cechetto

5

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9 December 2017

Eric D Brown

7

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9 December 2017

1 October 2004

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9 December 2017

Chemistry and Biology

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9 December 2017

11

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9 December 2017

1445-1453

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9 December 2017

10

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A novel coronavirus associated with severe acute respiratory syndrome

9 December 2017

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12 December 2020

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

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12 December 2020

Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

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12 December 2020

Old drugs for a new bug: influenza, HIV drugs enlisted to fight SARS.

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12 December 2020

Mechanisms and enzymes involved in SARS coronavirus genome expression

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12 December 2020

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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12 December 2020

Mechanistic considerations in high-throughput screening

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12 December 2020

Viral replicase gene products suffice for coronavirus discontinuous transcription

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12 December 2020

3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism

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12 December 2020

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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12 December 2020

Highly specific inactivation of triosephosphate isomerase from Trypanosoma cruzi

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12 December 2020

Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction

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12 December 2020

Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases

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12 December 2020

Fluorogenic substrates for proteases based on intramolecular fluorescence energy transfer (IFETS)

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12 December 2020

Hyperexpression of a synthetic gene encoding a high potential iron sulfur protein.

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12 December 2020

An Escherichia coli host strain useful for efficient overproduction of cloned gene products with NaCl as the inducer

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12 December 2020

Common Adverse Events Associated with the Use of Ribavirin for Severe Acute Respiratory Syndrome in Canada

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12 December 2020

A major outbreak of severe acute respiratory syndrome in Hong Kong

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12 December 2020

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

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12 December 2020

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes

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12 December 2020

Expression and characterization of recombinant hepatitis A virus 3C proteinase

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12 December 2020

Small molecules targeting severe acute respiratory syndrome human coronavirus

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12 December 2020

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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12 December 2020

Virus-encoded proteinases and proteolytic processing in the Nidovirales.

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12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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12 December 2020

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.

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12 December 2020

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate

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12 December 2020

Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points

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12 December 2020

Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity

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12 December 2020

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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12 December 2020

Aetiology: Koch's postulates fulfilled for SARS virus

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12 December 2020

Outcome of coronavirus-associated severe acute respiratory syndrome using a standard treatment protocol

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12 December 2020

Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs

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12 December 2020

Identifying inhibitors of the SARS coronavirus proteinase

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12 December 2020

A 3D model of SARS_CoV 3CL proteinase and its inhibitors design by virtual screening.

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12 December 2020

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

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12 December 2020

Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.

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12 December 2020

Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design

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12 December 2020

The Genome sequence of the SARS-associated coronavirus

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12 December 2020

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

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12 December 2020

Cysteine Proteases and Their Inhibitors

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12 December 2020

10.1016/J.CHEMBIOL.2004.08.011

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DOI

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9 December 2017

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