(Q45158558)

10 December 2017

Effects of rapamycin in the Eker rat model of tuberous sclerosis complex (English)

1 reference

10 December 2017

1 reference

1 reference

Heidi Kenerson

1

1 reference

10 December 2017

Trevor A Dundon

series ordinal

2

1 reference

10 December 2017

Raymond S Yeung

series ordinal

3

1 reference

10 December 2017

language of work or name

English

0 references

publication date

19 November 2004

1 reference

10 December 2017

1 reference

10 December 2017

57

1 reference

10 December 2017

67-75

1 reference

10 December 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1203/01.pdr.0000147727.78571.07

10 December 2017

0 references

cites work

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Two genetic hits (more or less) to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Genetic identification of a locus, Mot1, that affects renal tumor size in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Rapamycins: mechanism of action and cellular resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

The tuberin-hamartin complex negatively regulates beta-catenin signaling activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F01.PDR.0000147727.78571.07

10.1203/01.PDR.0000147727.78571.07

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

10 December 2017

0 references

1 reference