(Q45314363)

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Signaling by cytosolic FGFR1 fusion mutants

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1839117)

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8 July 2022

FGFR1 mutant receptor activation

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13 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-1839117

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8 July 2022

Dimerization of cytosolic FGFR1 fusion proteins

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8 July 2022

Phosphorylation of cytosolic FGFR1 fusion dimers

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8 July 2022

Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation

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8 July 2022

Cytosolic FGFR1 fusion proteins bind PIK3R1

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8 July 2022

Activated cytosolic FGFR1 fusions bind PIK3CA

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8 July 2022

Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3

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8 July 2022

Phosphorylation of BCR moiety of BCR-FGFR1

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8 July 2022

p-BCR-pFGFR1 binds GRB2:GAB2

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8 July 2022

p-BCR-p-FGFR1 phosphorylates GAB2

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8 July 2022

BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1

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8 July 2022

BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA

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8 July 2022

BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.

1 reference

8 July 2022

Phosphorylation of STAT5 by cytosolic FGFR1 fusions

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8 July 2022

FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3

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8 July 2022

ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATS 1 and 5

1 reference

8 July 2022

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

1 reference

8 July 2022

Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome.

1 reference

8 July 2022

Fibroblast growth factors and their receptors in cancer

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8 July 2022

Targeting mutant fibroblast growth factor receptors in cancer

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8 July 2022

Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cgamma at the centrosome

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8 July 2022

Fibroblast growth factor signalling: from development to cancer

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8 July 2022

The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).

1 reference

8 July 2022

8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

1 reference

8 July 2022

Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation

1 reference

8 July 2022

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

1 reference

8 July 2022

8p11 myeloproliferative syndrome: a review.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45314363)

Signaling by cytosolic FGFR1 fusion mutants

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