(Q45317127)

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Interleukin-3, Interleukin-5 and GM-CSF signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-512988)

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8 July 2022

cytokine-mediated signaling pathway

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Signaling by Interleukins

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https://identifiers.org/reactome:R-HSA-512988

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Interleukin receptor SHC signaling

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Regulation of signaling by CBL

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STAT5 dimers translocate to the nucleus

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The common beta chain IL3RB binds JAK2

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GM-CSF receptor alpha subunit binds GM-CSF

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GM-CSF receptor alpha:GM-CSF binds Bc

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Interleukin-5 is a homodimer

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Interleukin-5 receptor alpha subunit binds Interleukin-5

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Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

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Interleukin-3 receptor alpha subunit binds Interleukin-3

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Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2

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The receptor is activated

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JAK2 is phosphorylated, activated

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STAT5 is recruited by JAK2

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Activation of STAT5a/b by JAK2

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p-STAT5 dissociates from the receptor complex

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Tyrosine kinases phosphorylate the receptor

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Recruitment of SHC1 is mediated by Y593 of the common beta chain

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SHC1 bound to the common beta chain becomes tyrosine phosphorylated

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IL3 stimulation induces Vav binding to Tec kinase

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SHP1 and SHP2 bind the common beta chain

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SHP1 and SHP2 dephosphorylate Y628 of IL3RB

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SHP2 can recruit GRB2

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IL3RB is phosphorylated on Ser-585

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p-S585-IL3RB binds 14-3-3 proteins

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14-3-3 zeta binding allows recruitment of PI3K

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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8 July 2022

Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317127)

Interleukin-3, Interleukin-5 and GM-CSF signaling

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