(Q45317729)

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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-381426)

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8 July 2022

Metabolism of proteins

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https://identifiers.org/reactome:R-HSA-381426

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FAM20C phosphorylates FAM20C substrates

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IGFBP1 binds IGF forming IGF:IGFBP1

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IGFBP2 binds IGF forming IGF:IGFBP2

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Formation of the IGF:IGFBP3:ALS complex

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IGFBP4 binds IGF forming IGF:IGFBP4

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Formation of the IGF:IGFBP5:ALS complex

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IGFBP6 binds IGF forming IGF:IGFBP6

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Cathepsin G proteolyzes IGF:IGFBP3:ALS

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Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

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Plasmin proteolyzes IGF:IGFBP-3:ALS

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Thrombin proteolyzes IGF:IGFBP3:ALS

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Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS

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PAAP-A proteolyzes IGF:IGFBP4

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PAPP-A2 proteolyzes IGF:IGFBP5:ALS

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IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

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Cellular actions of the insulin-like growth factor binding proteins

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Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?

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IGF-binding protein-4: biochemical characteristics and functional consequences

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The role of insulin-like growth factor binding proteins.

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Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317729)

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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