(Q45318330)

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PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8849471)

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8 July 2022

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https://identifiers.org/reactome:R-HSA-8849471

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PTK6 phosphorylates PXN

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Phosphorylated PXN recruits the CRK complex

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Activation of RAC1 by the PXN:CRK complex

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PTK6 phosphorylates ARHGAP35

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ARHGAP35 binds RHOA:GTP

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ARHGAP35 stimulates RHOA GTPase activity

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RASA1 stimulates RAS GTPase activity

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PTK6 phosphorylates BCAR1

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Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

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Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin

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Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrate

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Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45318330)

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

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